The etiopathogenesis of Parkinson disease and suggestions for future research. Part I

Irene Litvan, Glenda Halliday, Mark Hallett, Christopher G. Goetz, Walter Rocca, Charles Duyckaerts, Yoav Ben-Shlomo, Dennis W. Dickson, Anthony E. Lang, Marie Francoise Chesselet, William J. Langston, Donato A. Di Monte, Thomas Gasser, Theo Hagg, John Hardy, Peter Jenner, Eldad Melamed, Richard H. Myers, Davis Parker, Donald L. Price

Research output: Contribution to journalArticle

Abstract

We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors and, although there is extensive new information on the etiology and pathogenesis of PD that may advance its treatment, new syntheses of this information are needed. The first part of this two-part, state-of-the-art review by leaders in Parkinson research critically examines the field to identify where new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part I include the definition of the disease, neuropathologic contributions, and epidemiologic, environmental, and demographic issues.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume66
Issue number4
DOIs
StatePublished - Apr 2007

Fingerprint

Parkinson Disease
Demography
Research

Keywords

  • Lewy bodies
  • Parkinson disease
  • Synucleinopathies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Litvan, I., Halliday, G., Hallett, M., Goetz, C. G., Rocca, W., Duyckaerts, C., ... Price, D. L. (2007). The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. Journal of Neuropathology and Experimental Neurology, 66(4), 251-257. https://doi.org/10.1097/nen.0b013e3180415e42

The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. / Litvan, Irene; Halliday, Glenda; Hallett, Mark; Goetz, Christopher G.; Rocca, Walter; Duyckaerts, Charles; Ben-Shlomo, Yoav; Dickson, Dennis W.; Lang, Anthony E.; Chesselet, Marie Francoise; Langston, William J.; Di Monte, Donato A.; Gasser, Thomas; Hagg, Theo; Hardy, John; Jenner, Peter; Melamed, Eldad; Myers, Richard H.; Parker, Davis; Price, Donald L.

In: Journal of Neuropathology and Experimental Neurology, Vol. 66, No. 4, 04.2007, p. 251-257.

Research output: Contribution to journalArticle

Litvan, I, Halliday, G, Hallett, M, Goetz, CG, Rocca, W, Duyckaerts, C, Ben-Shlomo, Y, Dickson, DW, Lang, AE, Chesselet, MF, Langston, WJ, Di Monte, DA, Gasser, T, Hagg, T, Hardy, J, Jenner, P, Melamed, E, Myers, RH, Parker, D & Price, DL 2007, 'The etiopathogenesis of Parkinson disease and suggestions for future research. Part I', Journal of Neuropathology and Experimental Neurology, vol. 66, no. 4, pp. 251-257. https://doi.org/10.1097/nen.0b013e3180415e42
Litvan, Irene ; Halliday, Glenda ; Hallett, Mark ; Goetz, Christopher G. ; Rocca, Walter ; Duyckaerts, Charles ; Ben-Shlomo, Yoav ; Dickson, Dennis W. ; Lang, Anthony E. ; Chesselet, Marie Francoise ; Langston, William J. ; Di Monte, Donato A. ; Gasser, Thomas ; Hagg, Theo ; Hardy, John ; Jenner, Peter ; Melamed, Eldad ; Myers, Richard H. ; Parker, Davis ; Price, Donald L. / The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. In: Journal of Neuropathology and Experimental Neurology. 2007 ; Vol. 66, No. 4. pp. 251-257.
@article{6bc4643103244a669b4e7abc78104866,
title = "The etiopathogenesis of Parkinson disease and suggestions for future research. Part I",
abstract = "We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors and, although there is extensive new information on the etiology and pathogenesis of PD that may advance its treatment, new syntheses of this information are needed. The first part of this two-part, state-of-the-art review by leaders in Parkinson research critically examines the field to identify where new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part I include the definition of the disease, neuropathologic contributions, and epidemiologic, environmental, and demographic issues.",
keywords = "Lewy bodies, Parkinson disease, Synucleinopathies",
author = "Irene Litvan and Glenda Halliday and Mark Hallett and Goetz, {Christopher G.} and Walter Rocca and Charles Duyckaerts and Yoav Ben-Shlomo and Dickson, {Dennis W.} and Lang, {Anthony E.} and Chesselet, {Marie Francoise} and Langston, {William J.} and {Di Monte}, {Donato A.} and Thomas Gasser and Theo Hagg and John Hardy and Peter Jenner and Eldad Melamed and Myers, {Richard H.} and Davis Parker and Price, {Donald L.}",
year = "2007",
month = "4",
doi = "10.1097/nen.0b013e3180415e42",
language = "English (US)",
volume = "66",
pages = "251--257",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - The etiopathogenesis of Parkinson disease and suggestions for future research. Part I

AU - Litvan, Irene

AU - Halliday, Glenda

AU - Hallett, Mark

AU - Goetz, Christopher G.

AU - Rocca, Walter

AU - Duyckaerts, Charles

AU - Ben-Shlomo, Yoav

AU - Dickson, Dennis W.

AU - Lang, Anthony E.

AU - Chesselet, Marie Francoise

AU - Langston, William J.

AU - Di Monte, Donato A.

AU - Gasser, Thomas

AU - Hagg, Theo

AU - Hardy, John

AU - Jenner, Peter

AU - Melamed, Eldad

AU - Myers, Richard H.

AU - Parker, Davis

AU - Price, Donald L.

PY - 2007/4

Y1 - 2007/4

N2 - We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors and, although there is extensive new information on the etiology and pathogenesis of PD that may advance its treatment, new syntheses of this information are needed. The first part of this two-part, state-of-the-art review by leaders in Parkinson research critically examines the field to identify where new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part I include the definition of the disease, neuropathologic contributions, and epidemiologic, environmental, and demographic issues.

AB - We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors and, although there is extensive new information on the etiology and pathogenesis of PD that may advance its treatment, new syntheses of this information are needed. The first part of this two-part, state-of-the-art review by leaders in Parkinson research critically examines the field to identify where new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part I include the definition of the disease, neuropathologic contributions, and epidemiologic, environmental, and demographic issues.

KW - Lewy bodies

KW - Parkinson disease

KW - Synucleinopathies

UR - http://www.scopus.com/inward/record.url?scp=34147101621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34147101621&partnerID=8YFLogxK

U2 - 10.1097/nen.0b013e3180415e42

DO - 10.1097/nen.0b013e3180415e42

M3 - Article

C2 - 17413315

AN - SCOPUS:34147101621

VL - 66

SP - 251

EP - 257

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 4

ER -