The Etiology of Neuronal Development in Craniosynostosis

A Working Hypothesis

Eric D. Brooks, Joel S. Beckett, Jenny Yang, Andrew T. Timberlake, Alexander Sun, Carolyn Chuang, John A. Persing

Research output: Contribution to journalArticle

Abstract

Craniosynostosis is one of the most common craniofacial conditions treated by neurologic and plastic surgeons. In addition to disfigurement, children with craniosynostosis experience significant cognitive dysfunction later in life. Surgery is performed in infancy to correct skull deformity; however, the field is at a crossroads regarding the best approach for correction. Since the cause of brain dysfunction in these patients has remained uncertain, the role and type of surgery might have in attenuating the later-observed cognitive deficits through impact on the brain has been unclear. Recently, however, advances in imaging such as event-related potentials, diffusion tensor imaging, and functional MRI, in conjunction with more robust clinical studies, are providing important insight into the potential etiologies of brain dysfunction in syndromic and nonsyndromic craniosynostosis patients. This review aims to outline the cause(s) of such brain dysfunction including the role extrinsic vault constriction might have on brain development and the current evidence for an intrinsic modular developmental error in brain development. Illuminating the cause of brain dysfunction will identify the role of surgery can play in improving observed functional deficits and thus direct optimal primary and adjuvant treatment.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalJournal of Craniofacial Surgery
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Craniosynostoses
Brain
Diffusion Tensor Imaging
Evoked Potentials
Skull
Constriction
Nervous System
Magnetic Resonance Imaging

Keywords

  • Craniofacial
  • craniosynostosis
  • diffusion tensor imaging
  • event-related potential
  • functional MRI
  • neurocognitive
  • neuroimaging

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Brooks, E. D., Beckett, J. S., Yang, J., Timberlake, A. T., Sun, A., Chuang, C., & Persing, J. A. (2018). The Etiology of Neuronal Development in Craniosynostosis: A Working Hypothesis. Journal of Craniofacial Surgery, 29(1), 49-55. https://doi.org/10.1097/SCS.0000000000004040

The Etiology of Neuronal Development in Craniosynostosis : A Working Hypothesis. / Brooks, Eric D.; Beckett, Joel S.; Yang, Jenny; Timberlake, Andrew T.; Sun, Alexander; Chuang, Carolyn; Persing, John A.

In: Journal of Craniofacial Surgery, Vol. 29, No. 1, 01.01.2018, p. 49-55.

Research output: Contribution to journalArticle

Brooks, ED, Beckett, JS, Yang, J, Timberlake, AT, Sun, A, Chuang, C & Persing, JA 2018, 'The Etiology of Neuronal Development in Craniosynostosis: A Working Hypothesis', Journal of Craniofacial Surgery, vol. 29, no. 1, pp. 49-55. https://doi.org/10.1097/SCS.0000000000004040
Brooks, Eric D. ; Beckett, Joel S. ; Yang, Jenny ; Timberlake, Andrew T. ; Sun, Alexander ; Chuang, Carolyn ; Persing, John A. / The Etiology of Neuronal Development in Craniosynostosis : A Working Hypothesis. In: Journal of Craniofacial Surgery. 2018 ; Vol. 29, No. 1. pp. 49-55.
@article{b75840552fa6496fb671c9a809ac4fee,
title = "The Etiology of Neuronal Development in Craniosynostosis: A Working Hypothesis",
abstract = "Craniosynostosis is one of the most common craniofacial conditions treated by neurologic and plastic surgeons. In addition to disfigurement, children with craniosynostosis experience significant cognitive dysfunction later in life. Surgery is performed in infancy to correct skull deformity; however, the field is at a crossroads regarding the best approach for correction. Since the cause of brain dysfunction in these patients has remained uncertain, the role and type of surgery might have in attenuating the later-observed cognitive deficits through impact on the brain has been unclear. Recently, however, advances in imaging such as event-related potentials, diffusion tensor imaging, and functional MRI, in conjunction with more robust clinical studies, are providing important insight into the potential etiologies of brain dysfunction in syndromic and nonsyndromic craniosynostosis patients. This review aims to outline the cause(s) of such brain dysfunction including the role extrinsic vault constriction might have on brain development and the current evidence for an intrinsic modular developmental error in brain development. Illuminating the cause of brain dysfunction will identify the role of surgery can play in improving observed functional deficits and thus direct optimal primary and adjuvant treatment.",
keywords = "Craniofacial, craniosynostosis, diffusion tensor imaging, event-related potential, functional MRI, neurocognitive, neuroimaging",
author = "Brooks, {Eric D.} and Beckett, {Joel S.} and Jenny Yang and Timberlake, {Andrew T.} and Alexander Sun and Carolyn Chuang and Persing, {John A.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1097/SCS.0000000000004040",
language = "English (US)",
volume = "29",
pages = "49--55",
journal = "Journal of Craniofacial Surgery",
issn = "1049-2275",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - The Etiology of Neuronal Development in Craniosynostosis

T2 - A Working Hypothesis

AU - Brooks, Eric D.

AU - Beckett, Joel S.

AU - Yang, Jenny

AU - Timberlake, Andrew T.

AU - Sun, Alexander

AU - Chuang, Carolyn

AU - Persing, John A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Craniosynostosis is one of the most common craniofacial conditions treated by neurologic and plastic surgeons. In addition to disfigurement, children with craniosynostosis experience significant cognitive dysfunction later in life. Surgery is performed in infancy to correct skull deformity; however, the field is at a crossroads regarding the best approach for correction. Since the cause of brain dysfunction in these patients has remained uncertain, the role and type of surgery might have in attenuating the later-observed cognitive deficits through impact on the brain has been unclear. Recently, however, advances in imaging such as event-related potentials, diffusion tensor imaging, and functional MRI, in conjunction with more robust clinical studies, are providing important insight into the potential etiologies of brain dysfunction in syndromic and nonsyndromic craniosynostosis patients. This review aims to outline the cause(s) of such brain dysfunction including the role extrinsic vault constriction might have on brain development and the current evidence for an intrinsic modular developmental error in brain development. Illuminating the cause of brain dysfunction will identify the role of surgery can play in improving observed functional deficits and thus direct optimal primary and adjuvant treatment.

AB - Craniosynostosis is one of the most common craniofacial conditions treated by neurologic and plastic surgeons. In addition to disfigurement, children with craniosynostosis experience significant cognitive dysfunction later in life. Surgery is performed in infancy to correct skull deformity; however, the field is at a crossroads regarding the best approach for correction. Since the cause of brain dysfunction in these patients has remained uncertain, the role and type of surgery might have in attenuating the later-observed cognitive deficits through impact on the brain has been unclear. Recently, however, advances in imaging such as event-related potentials, diffusion tensor imaging, and functional MRI, in conjunction with more robust clinical studies, are providing important insight into the potential etiologies of brain dysfunction in syndromic and nonsyndromic craniosynostosis patients. This review aims to outline the cause(s) of such brain dysfunction including the role extrinsic vault constriction might have on brain development and the current evidence for an intrinsic modular developmental error in brain development. Illuminating the cause of brain dysfunction will identify the role of surgery can play in improving observed functional deficits and thus direct optimal primary and adjuvant treatment.

KW - Craniofacial

KW - craniosynostosis

KW - diffusion tensor imaging

KW - event-related potential

KW - functional MRI

KW - neurocognitive

KW - neuroimaging

UR - http://www.scopus.com/inward/record.url?scp=85039737944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039737944&partnerID=8YFLogxK

U2 - 10.1097/SCS.0000000000004040

DO - 10.1097/SCS.0000000000004040

M3 - Article

VL - 29

SP - 49

EP - 55

JO - Journal of Craniofacial Surgery

JF - Journal of Craniofacial Surgery

SN - 1049-2275

IS - 1

ER -