The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

Qing Lin; Mingcai Li; Dan Fang; Jiazhu Fang; Shao Bo Su

doi:10.1016/j.intimp.2011.04.026

The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

Qing Lin, Mingcai Li, Dan Fang, Jiazhu Fang, Shao Bo Su

Research output: Contribution to journal › Review article › peer-review

Abstract

Toll-like receptors (TLRs) form a family of pattern recognition receptors with at least 11 members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived agonists that have emerged as key mediators of innate immunity. TLR signaling also plays an important role in the activation of the adaptive immune system by inducing pro-inflammatory cytokines and upregulating costimulatory molecules of antigen presenting cells. Inappropriate activation of TLRs by self-components generated by damaged tissues may result in sterile inflammation. This review discusses the contribution of TLR signaling to the initiation and progression of non-infectious inflammatory processes, such as ischemia and reperfusion (I/R) injury, tissue repair and regeneration and autoimmune diseases. The involvement of TLR signaling in the pathogenesis of sterile inflammation-related diseases may provide novel targets for the development of therapeutics.

Original language	English (US)
Pages (from-to)	1422-1432
Number of pages	11
Journal	International immunopharmacology
Volume	11
Issue number	10
DOIs	https://doi.org/10.1016/j.intimp.2011.04.026
State	Published - Oct 2011
Externally published	Yes

Keywords

Autoimmunity
Ligands
Sterile inflammation
Toll-like receptors

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

Access to Document

10.1016/j.intimp.2011.04.026

Cite this

@article{82a78c6606a246a9b892348cf3bc05de,

title = "The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases",

abstract = "Toll-like receptors (TLRs) form a family of pattern recognition receptors with at least 11 members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived agonists that have emerged as key mediators of innate immunity. TLR signaling also plays an important role in the activation of the adaptive immune system by inducing pro-inflammatory cytokines and upregulating costimulatory molecules of antigen presenting cells. Inappropriate activation of TLRs by self-components generated by damaged tissues may result in sterile inflammation. This review discusses the contribution of TLR signaling to the initiation and progression of non-infectious inflammatory processes, such as ischemia and reperfusion (I/R) injury, tissue repair and regeneration and autoimmune diseases. The involvement of TLR signaling in the pathogenesis of sterile inflammation-related diseases may provide novel targets for the development of therapeutics.",

keywords = "Autoimmunity, Ligands, Sterile inflammation, Toll-like receptors",

author = "Qing Lin and Mingcai Li and Dan Fang and Jiazhu Fang and Su, {Shao Bo}",

note = "Funding Information: We are grateful for the critical comments by Dr. Ji Ming Wang (NCI, NIH). This project was supported by the grants from the National Natural Science Foundation of China ( 81072483 ).",

year = "2011",

month = oct,

doi = "10.1016/j.intimp.2011.04.026",

language = "English (US)",

volume = "11",

pages = "1422--1432",

journal = "International Immunopharmacology",

issn = "1567-5769",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

AU - Lin, Qing

AU - Li, Mingcai

AU - Fang, Dan

AU - Fang, Jiazhu

AU - Su, Shao Bo

N1 - Funding Information: We are grateful for the critical comments by Dr. Ji Ming Wang (NCI, NIH). This project was supported by the grants from the National Natural Science Foundation of China ( 81072483 ).

PY - 2011/10

Y1 - 2011/10

N2 - Toll-like receptors (TLRs) form a family of pattern recognition receptors with at least 11 members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived agonists that have emerged as key mediators of innate immunity. TLR signaling also plays an important role in the activation of the adaptive immune system by inducing pro-inflammatory cytokines and upregulating costimulatory molecules of antigen presenting cells. Inappropriate activation of TLRs by self-components generated by damaged tissues may result in sterile inflammation. This review discusses the contribution of TLR signaling to the initiation and progression of non-infectious inflammatory processes, such as ischemia and reperfusion (I/R) injury, tissue repair and regeneration and autoimmune diseases. The involvement of TLR signaling in the pathogenesis of sterile inflammation-related diseases may provide novel targets for the development of therapeutics.

AB - Toll-like receptors (TLRs) form a family of pattern recognition receptors with at least 11 members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived agonists that have emerged as key mediators of innate immunity. TLR signaling also plays an important role in the activation of the adaptive immune system by inducing pro-inflammatory cytokines and upregulating costimulatory molecules of antigen presenting cells. Inappropriate activation of TLRs by self-components generated by damaged tissues may result in sterile inflammation. This review discusses the contribution of TLR signaling to the initiation and progression of non-infectious inflammatory processes, such as ischemia and reperfusion (I/R) injury, tissue repair and regeneration and autoimmune diseases. The involvement of TLR signaling in the pathogenesis of sterile inflammation-related diseases may provide novel targets for the development of therapeutics.

KW - Autoimmunity

KW - Ligands

KW - Sterile inflammation

KW - Toll-like receptors

UR - http://www.scopus.com/inward/record.url?scp=80053221916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053221916&partnerID=8YFLogxK

U2 - 10.1016/j.intimp.2011.04.026

DO - 10.1016/j.intimp.2011.04.026

M3 - Review article

C2 - 21600309

AN - SCOPUS:80053221916

VL - 11

SP - 1422

EP - 1432

JO - International Immunopharmacology

JF - International Immunopharmacology

SN - 1567-5769

IS - 10

ER -

The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this