The erythrocyte urea transporter UT-B

Research output: Contribution to journalArticle

Abstract

During the past decade significant progress has been made in our understanding of the role played by urea transporters in the production of concentrated urine by the kidney. Urea transporters have been cloned and characterized in a wide range of species. The genomic organization of the two major families of mammalian urea transporters, UT-A and UT-B, has been defined, providing new insight into the mechanisms that regulate their expression and function in physiological and pathological conditions. Beside the kidney, the presence of urea transporters has been documented in a variety of tissues, where their role is not fully known. Recently, mice with targeted deletion of the major urea transporters have been generated, which have shown variable impairment of urine concentrating ability, and have helped to clarify the physiological contribution of individual transporters to this process. This review focuses on the erythrocyte urea transporter UT-B.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Membrane Biology
Volume212
Issue number2
DOIs
StatePublished - Sep 2006

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Erythrocytes
Kidney Concentrating Ability
Kidney
urea transporter
Urine

Keywords

  • Colon
  • Erythrocyte
  • Kidney
  • Urea Transport
  • Urine concentration
  • Vasa recta

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Cell Biology

Cite this

The erythrocyte urea transporter UT-B. / Bagnasco, Serena M.

In: Journal of Membrane Biology, Vol. 212, No. 2, 09.2006, p. 133-138.

Research output: Contribution to journalArticle

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