The Epigenomics of Cancer

Peter A. Jones, Stephen B Baylin

Research output: Contribution to journalArticle

Abstract

Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.

Original languageEnglish (US)
Pages (from-to)683-692
Number of pages10
JournalCell
Volume128
Issue number4
DOIs
StatePublished - Feb 23 2007

    Fingerprint

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this