The Epigenomics of Cancer

Peter A. Jones, Stephen B Baylin

Research output: Contribution to journalArticle

Abstract

Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.

Original languageEnglish (US)
Pages (from-to)683-692
Number of pages10
JournalCell
Volume128
Issue number4
DOIs
StatePublished - Feb 23 2007

Fingerprint

Epigenomics
Gene expression
Genes
Neoplasms
Stem Cells
Gene Expression

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

The Epigenomics of Cancer. / Jones, Peter A.; Baylin, Stephen B.

In: Cell, Vol. 128, No. 4, 23.02.2007, p. 683-692.

Research output: Contribution to journalArticle

Jones, Peter A. ; Baylin, Stephen B. / The Epigenomics of Cancer. In: Cell. 2007 ; Vol. 128, No. 4. pp. 683-692.
@article{230da6d496cc4e94ac943d9b3872d411,
title = "The Epigenomics of Cancer",
abstract = "Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.",
author = "Jones, {Peter A.} and Baylin, {Stephen B}",
year = "2007",
month = "2",
day = "23",
doi = "10.1016/j.cell.2007.01.029",
language = "English (US)",
volume = "128",
pages = "683--692",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - The Epigenomics of Cancer

AU - Jones, Peter A.

AU - Baylin, Stephen B

PY - 2007/2/23

Y1 - 2007/2/23

N2 - Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.

AB - Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.

UR - http://www.scopus.com/inward/record.url?scp=33847065486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847065486&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2007.01.029

DO - 10.1016/j.cell.2007.01.029

M3 - Article

VL - 128

SP - 683

EP - 692

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -