The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)

Robyn T. Sussman; Timothy J. Stanek; Paul Esteso; John D. Gearhart; Karen E. Knudsen; Steven B. McMahon

doi:10.1074/jbc.M113.469783

The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)

Robyn T. Sussman, Timothy J. Stanek, Paul Esteso, John D. Gearhart, Karen E. Knudsen, Steven B. McMahon

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background: Ubiquitin-specific protease 22 (USP22) is a deubiquitylating enzyme with established biological functions in cancer cells. Results: USP22 drives differentiation of embryonic stem cells (ESCs) and represses sex-determining region Y-box 2 (SOX2) transcription. Conclusion: USP22 is induced during ESC differentiation to repress SOX2 transcription. Significance: Understanding the epigenetic programs that control changes in gene expression during the transition from self-renewal to differentiation.

Original language	English (US)
Pages (from-to)	24234-24246
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.469783
State	Published - Aug 16 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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Sussman, R. T., Stanek, T. J., Esteso, P., Gearhart, J. D., Knudsen, K. E., & McMahon, S. B. (2013). The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2). Journal of Biological Chemistry, 288(33), 24234-24246. https://doi.org/10.1074/jbc.M113.469783

The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2). / Sussman, Robyn T.; Stanek, Timothy J.; Esteso, Paul et al.

In: Journal of Biological Chemistry, Vol. 288, No. 33, 16.08.2013, p. 24234-24246.

Research output: Contribution to journal › Article › peer-review

Sussman, RT, Stanek, TJ, Esteso, P, Gearhart, JD, Knudsen, KE & McMahon, SB 2013, 'The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)', Journal of Biological Chemistry, vol. 288, no. 33, pp. 24234-24246. https://doi.org/10.1074/jbc.M113.469783

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The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)

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