Abstract
Background: Ubiquitin-specific protease 22 (USP22) is a deubiquitylating enzyme with established biological functions in cancer cells. Results: USP22 drives differentiation of embryonic stem cells (ESCs) and represses sex-determining region Y-box 2 (SOX2) transcription. Conclusion: USP22 is induced during ESC differentiation to repress SOX2 transcription. Significance: Understanding the epigenetic programs that control changes in gene expression during the transition from self-renewal to differentiation.
Original language | English (US) |
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Pages (from-to) | 24234-24246 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 33 |
DOIs | |
State | Published - Aug 16 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology