Abstract
Background: Recent studies indicate that subclavian stenosis (SS), diagnosed by a large systolic blood pressure difference (SBPD) between the right and left brachial arteries, is associated with cardiovascular disease (CVD) risk factors and outcomes. We sought to describe the epidemiology of SS and determine its association with markers of subclinical CVD in the baseline cohort of the Multi-Ethnic Study of Atherosclerosis. Methods: We defined SS by an absolute SBPD ≥15. mmHg. Peripheral artery disease (PAD) was defined by an ankle-brachial index ≤0.90. The coronary artery calcium score (CAC) and the common carotid artery intima-media thickness (CCA-IMT) were measured by computed tomography and B-mode ultrasound, respectively. Odds ratios for the associations of SS with risk factors and subclinical disease were estimated using logistic regression. Results: Of 6743 subjects studied, 307 participants (4.6%) had SS, with a higher prevalence in women (5.1%) than men (3.9%), and in African Americans (7.4%) and non-Hispanic whites (5.1%) than Hispanic (1.9%) or Chinese (1.0%) participants (p100 vs. score = 0; OR = 1.43; 1.03-2.01). Conclusions: The subclavian stenosis is positively associated with other markers of subclinical atherosclerosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 266-270 |
| Number of pages | 5 |
| Journal | Atherosclerosis |
| Volume | 211 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2010 |
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Keywords
- Atherosclerosis
- Blood pressure
- Epidemiology
- Subclavian artery
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Medicine(all)
Cite this
The epidemiology of subclavian stenosis and its association with markers of subclinical atherosclerosis : The Multi-Ethnic Study of Atherosclerosis (MESA). / Aboyans, Victor; Kamineni, Aruna; Allison, Matthew A.; McDermott, Mary McGrae; Crouse, John R.; Ni, Hanyu; Szklo, Moyses; Criqui, Michael H.
In: Atherosclerosis, Vol. 211, No. 1, 07.2010, p. 266-270.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The epidemiology of subclavian stenosis and its association with markers of subclinical atherosclerosis
T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)
AU - Aboyans, Victor
AU - Kamineni, Aruna
AU - Allison, Matthew A.
AU - McDermott, Mary McGrae
AU - Crouse, John R.
AU - Ni, Hanyu
AU - Szklo, Moyses
AU - Criqui, Michael H.
PY - 2010/7
Y1 - 2010/7
N2 - Background: Recent studies indicate that subclavian stenosis (SS), diagnosed by a large systolic blood pressure difference (SBPD) between the right and left brachial arteries, is associated with cardiovascular disease (CVD) risk factors and outcomes. We sought to describe the epidemiology of SS and determine its association with markers of subclinical CVD in the baseline cohort of the Multi-Ethnic Study of Atherosclerosis. Methods: We defined SS by an absolute SBPD ≥15. mmHg. Peripheral artery disease (PAD) was defined by an ankle-brachial index ≤0.90. The coronary artery calcium score (CAC) and the common carotid artery intima-media thickness (CCA-IMT) were measured by computed tomography and B-mode ultrasound, respectively. Odds ratios for the associations of SS with risk factors and subclinical disease were estimated using logistic regression. Results: Of 6743 subjects studied, 307 participants (4.6%) had SS, with a higher prevalence in women (5.1%) than men (3.9%), and in African Americans (7.4%) and non-Hispanic whites (5.1%) than Hispanic (1.9%) or Chinese (1.0%) participants (p100 vs. score = 0; OR = 1.43; 1.03-2.01). Conclusions: The subclavian stenosis is positively associated with other markers of subclinical atherosclerosis.
AB - Background: Recent studies indicate that subclavian stenosis (SS), diagnosed by a large systolic blood pressure difference (SBPD) between the right and left brachial arteries, is associated with cardiovascular disease (CVD) risk factors and outcomes. We sought to describe the epidemiology of SS and determine its association with markers of subclinical CVD in the baseline cohort of the Multi-Ethnic Study of Atherosclerosis. Methods: We defined SS by an absolute SBPD ≥15. mmHg. Peripheral artery disease (PAD) was defined by an ankle-brachial index ≤0.90. The coronary artery calcium score (CAC) and the common carotid artery intima-media thickness (CCA-IMT) were measured by computed tomography and B-mode ultrasound, respectively. Odds ratios for the associations of SS with risk factors and subclinical disease were estimated using logistic regression. Results: Of 6743 subjects studied, 307 participants (4.6%) had SS, with a higher prevalence in women (5.1%) than men (3.9%), and in African Americans (7.4%) and non-Hispanic whites (5.1%) than Hispanic (1.9%) or Chinese (1.0%) participants (p100 vs. score = 0; OR = 1.43; 1.03-2.01). Conclusions: The subclavian stenosis is positively associated with other markers of subclinical atherosclerosis.
KW - Atherosclerosis
KW - Blood pressure
KW - Epidemiology
KW - Subclavian artery
UR - http://www.scopus.com/inward/record.url?scp=77954314784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954314784&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2010.01.013
DO - 10.1016/j.atherosclerosis.2010.01.013
M3 - Article
C2 - 20138280
AN - SCOPUS:77954314784
VL - 211
SP - 266
EP - 270
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -