The epidemiology of rotavirus diarrhea in Latin America. Anticipating rotavirus vaccines

Erin Kane, Reina M. Turcios, Melissa L. Arvay, Salvador Garcia, Joseph S. Bresee, Roger I. Glass

Research output: Contribution to journalReview article

Abstract

Objective. To assess the disease burden and characterize the epidemiology of rotavirus diarrhea in Latin America. Methods. We conducted a literature review of studies of children <5 years of age who were hospitalized or seen as outpatients for diarrhea and for whom rotavirus was sought as the etiologic agent of the diarrhea. This review included inpatient and outpatient studies published since 1998 that included at least 100 children and reported surveillance activities lasting at least 12 consecutive months. Results. A total of 18 inpatient and 10 outpatient studies met the criteria for inclusion in this review. Rotavirus was detected in a median of 31% of inpatients (range, 16%-52%) and 30.5% of outpatients (range, 4%-42%). The median detection rate was higher in studies that used an enzyme-linked immunosorbent assay (ELISA) (inpatients 38%, outpatients 33%) versus less sensitive methods of detection. The age distribution of rotavirus disease varied among countries, with 65%-85% of children hospitalized in the first year of life. Most countries had rotavirus admissions year round, and rotavirus generally exhibited a winter seasonal peak in both temperate and tropical climates. Conclusions. The heavy burden of disease attributable to rotavirus in Latin America suggests that vaccines currently being tested could have considerable impact in preventing hospitalizations, clinic visits, and deaths. The findings of the young age distribution of patients highlight the importance of early immunization for the success of a vaccine program. The data suggest that future surveillance for rotavirus diarrhea in Latin America should use a standardized surveillance protocol with an ELISA for detection. Data from surveillance studies will be critical to monitor the impact of the future introduction of vaccines.

Original languageEnglish (US)
Pages (from-to)371-377
Number of pages7
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Volume16
Issue number6
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Rotavirus Vaccines
Latin America
Rotavirus
vaccine
epidemiology
surveillance
Diarrhea
Epidemiology
Disease
Outpatients
age structure
Inpatients
assay
enzyme
immunization
Vaccines
Age Distribution
literature review
hospitalization
Enzyme-Linked Immunosorbent Assay

Keywords

  • Burden of illness
  • Disease outbreaks
  • Epidemiology
  • Latin America
  • Rotavirus

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Geography, Planning and Development

Cite this

Kane, E., Turcios, R. M., Arvay, M. L., Garcia, S., Bresee, J. S., & Glass, R. I. (2004). The epidemiology of rotavirus diarrhea in Latin America. Anticipating rotavirus vaccines. Revista Panamericana de Salud Publica/Pan American Journal of Public Health, 16(6), 371-377.

The epidemiology of rotavirus diarrhea in Latin America. Anticipating rotavirus vaccines. / Kane, Erin; Turcios, Reina M.; Arvay, Melissa L.; Garcia, Salvador; Bresee, Joseph S.; Glass, Roger I.

In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health, Vol. 16, No. 6, 12.2004, p. 371-377.

Research output: Contribution to journalReview article

Kane, Erin ; Turcios, Reina M. ; Arvay, Melissa L. ; Garcia, Salvador ; Bresee, Joseph S. ; Glass, Roger I. / The epidemiology of rotavirus diarrhea in Latin America. Anticipating rotavirus vaccines. In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 2004 ; Vol. 16, No. 6. pp. 371-377.
@article{2292d38d1d6544b592d332af76da38c6,
title = "The epidemiology of rotavirus diarrhea in Latin America. Anticipating rotavirus vaccines",
abstract = "Objective. To assess the disease burden and characterize the epidemiology of rotavirus diarrhea in Latin America. Methods. We conducted a literature review of studies of children <5 years of age who were hospitalized or seen as outpatients for diarrhea and for whom rotavirus was sought as the etiologic agent of the diarrhea. This review included inpatient and outpatient studies published since 1998 that included at least 100 children and reported surveillance activities lasting at least 12 consecutive months. Results. A total of 18 inpatient and 10 outpatient studies met the criteria for inclusion in this review. Rotavirus was detected in a median of 31{\%} of inpatients (range, 16{\%}-52{\%}) and 30.5{\%} of outpatients (range, 4{\%}-42{\%}). The median detection rate was higher in studies that used an enzyme-linked immunosorbent assay (ELISA) (inpatients 38{\%}, outpatients 33{\%}) versus less sensitive methods of detection. The age distribution of rotavirus disease varied among countries, with 65{\%}-85{\%} of children hospitalized in the first year of life. Most countries had rotavirus admissions year round, and rotavirus generally exhibited a winter seasonal peak in both temperate and tropical climates. Conclusions. The heavy burden of disease attributable to rotavirus in Latin America suggests that vaccines currently being tested could have considerable impact in preventing hospitalizations, clinic visits, and deaths. The findings of the young age distribution of patients highlight the importance of early immunization for the success of a vaccine program. The data suggest that future surveillance for rotavirus diarrhea in Latin America should use a standardized surveillance protocol with an ELISA for detection. Data from surveillance studies will be critical to monitor the impact of the future introduction of vaccines.",
keywords = "Burden of illness, Disease outbreaks, Epidemiology, Latin America, Rotavirus",
author = "Erin Kane and Turcios, {Reina M.} and Arvay, {Melissa L.} and Salvador Garcia and Bresee, {Joseph S.} and Glass, {Roger I.}",
year = "2004",
month = "12",
language = "English (US)",
volume = "16",
pages = "371--377",
journal = "Revista Panamericana de Salud Publica/Pan American Journal of Public Health",
issn = "1020-4989",
publisher = "Pan American Health Organization",
number = "6",

}

TY - JOUR

T1 - The epidemiology of rotavirus diarrhea in Latin America. Anticipating rotavirus vaccines

AU - Kane, Erin

AU - Turcios, Reina M.

AU - Arvay, Melissa L.

AU - Garcia, Salvador

AU - Bresee, Joseph S.

AU - Glass, Roger I.

PY - 2004/12

Y1 - 2004/12

N2 - Objective. To assess the disease burden and characterize the epidemiology of rotavirus diarrhea in Latin America. Methods. We conducted a literature review of studies of children <5 years of age who were hospitalized or seen as outpatients for diarrhea and for whom rotavirus was sought as the etiologic agent of the diarrhea. This review included inpatient and outpatient studies published since 1998 that included at least 100 children and reported surveillance activities lasting at least 12 consecutive months. Results. A total of 18 inpatient and 10 outpatient studies met the criteria for inclusion in this review. Rotavirus was detected in a median of 31% of inpatients (range, 16%-52%) and 30.5% of outpatients (range, 4%-42%). The median detection rate was higher in studies that used an enzyme-linked immunosorbent assay (ELISA) (inpatients 38%, outpatients 33%) versus less sensitive methods of detection. The age distribution of rotavirus disease varied among countries, with 65%-85% of children hospitalized in the first year of life. Most countries had rotavirus admissions year round, and rotavirus generally exhibited a winter seasonal peak in both temperate and tropical climates. Conclusions. The heavy burden of disease attributable to rotavirus in Latin America suggests that vaccines currently being tested could have considerable impact in preventing hospitalizations, clinic visits, and deaths. The findings of the young age distribution of patients highlight the importance of early immunization for the success of a vaccine program. The data suggest that future surveillance for rotavirus diarrhea in Latin America should use a standardized surveillance protocol with an ELISA for detection. Data from surveillance studies will be critical to monitor the impact of the future introduction of vaccines.

AB - Objective. To assess the disease burden and characterize the epidemiology of rotavirus diarrhea in Latin America. Methods. We conducted a literature review of studies of children <5 years of age who were hospitalized or seen as outpatients for diarrhea and for whom rotavirus was sought as the etiologic agent of the diarrhea. This review included inpatient and outpatient studies published since 1998 that included at least 100 children and reported surveillance activities lasting at least 12 consecutive months. Results. A total of 18 inpatient and 10 outpatient studies met the criteria for inclusion in this review. Rotavirus was detected in a median of 31% of inpatients (range, 16%-52%) and 30.5% of outpatients (range, 4%-42%). The median detection rate was higher in studies that used an enzyme-linked immunosorbent assay (ELISA) (inpatients 38%, outpatients 33%) versus less sensitive methods of detection. The age distribution of rotavirus disease varied among countries, with 65%-85% of children hospitalized in the first year of life. Most countries had rotavirus admissions year round, and rotavirus generally exhibited a winter seasonal peak in both temperate and tropical climates. Conclusions. The heavy burden of disease attributable to rotavirus in Latin America suggests that vaccines currently being tested could have considerable impact in preventing hospitalizations, clinic visits, and deaths. The findings of the young age distribution of patients highlight the importance of early immunization for the success of a vaccine program. The data suggest that future surveillance for rotavirus diarrhea in Latin America should use a standardized surveillance protocol with an ELISA for detection. Data from surveillance studies will be critical to monitor the impact of the future introduction of vaccines.

KW - Burden of illness

KW - Disease outbreaks

KW - Epidemiology

KW - Latin America

KW - Rotavirus

UR - http://www.scopus.com/inward/record.url?scp=11244322139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11244322139&partnerID=8YFLogxK

M3 - Review article

C2 - 15673479

AN - SCOPUS:11244322139

VL - 16

SP - 371

EP - 377

JO - Revista Panamericana de Salud Publica/Pan American Journal of Public Health

JF - Revista Panamericana de Salud Publica/Pan American Journal of Public Health

SN - 1020-4989

IS - 6

ER -