@article{870d38300d90402faf6b6e9026497250,
title = "The entomopathogenic fungus Beauveria bassiana activate toll and JAK-STAT pathway-controlled effector genes and anti-dengue activity in Aedes aegypti",
abstract = "Here we investigated the effect of Beauveria bassiana infection on the survival of Aedes aegypti mosquitoes and the modulation of their susceptibility to dengue virus infection. Application of B.bassiana caused a reduction in the life span of A.aegypti and hindered dengue virus replication in the mosquito midgut. Fungus infection induced the expression a variety anti-microbial and dengue virus restriction factor genes. Transient reverse genetic analyses showed that the JAK-STAT pathway is implicated anti-fungal defense of Aedes mosquitoes. Our data suggest that this B.bassiana-mediated anti-dengue activity is likely to be at least partly indirectly mediated through the activation of the mosquito's anti-dengue Toll and JAK-STAT pathways.",
keywords = "Aedes aegypti, Beauveria bassiana, Dengue virus, Innate immunity",
author = "Yuemei Dong and Morton, {James C.} and Ramirez, {Jose Luis} and Souza-Neto, {Jayme A.} and George Dimopoulos",
note = "Funding Information: We thank the personnel at the Johns Hopkins Malaria Research Institute Insect Facility for assistance with mosquito rearing. We also thank the Arbovirus Diseases Branch at the CDC for providing the anti-dengue antibodies (mouse hyperimmune ascitic fluid). This work has been supported by the National Institutes of Health/National Institute of Allergy and Infectious Disease R01AI078997-02; R21AI090188-02 , a Johns Hopkins School of Public Health Faculty Innovation Grant, and the Johns Hopkins Malaria Research Institute. We also thank Dr. Deborah McClellan for editorial assistance. J.C.M. was supported by Johns Hopkins Diversity Research Internship Program, J.L.R. was supported by NIH individual NRSA training grant F31 AI080161-01A1 and by the American Society for Microbiology Robert D. Watkins Graduate Research Fellowship and J.A.S.-N. was supported by the Johns Hopkins Malaria Research Institute. ",
year = "2012",
month = feb,
doi = "10.1016/j.ibmb.2011.11.005",
language = "English (US)",
volume = "42",
pages = "126--132",
journal = "Insect Biochemistry and Molecular Biology",
issn = "0965-1748",
publisher = "Elsevier Limited",
number = "2",
}