The entirely carbohydrate immunogen Tn-PS A1 induces a cancer cell selective immune response and cytokine IL-17

Ravindra A. De Silva, Dananjaya K. Appulage, Halina Pietraszkiewicz, Kevin R. Bobbitt, Joe Media, Jia Jiu Shaw, Fred A. Valeriote, Peter R. Andreana

Research output: Contribution to journalArticlepeer-review

Abstract

The tumor-associated carbohydrate antigen/hapten Thomsen-nouveau (Tn; αNAc-ONH2) was conjugated to a zwitterionic capsular polysaccharide, PS A1, from commensal anaerobe Bacteroides fragilis ATCC 25285/NCTC 9343 for the development of an entirely carbohydrate cancer vaccine construct and probed for immunogenicity. This communication discloses that murine anti-Tn IgG3 antibodies both bind to and recognize human tumor cells that display the Tn hapten. Furthermore, the sera from immunization of mice with Tn-PS A1 contain cytokine interleukin 17 (IL-17A), which is known to possess anti-tumor function and represents a striking difference to an IL-2, and IL-6 profile obtained with anti-PS A1 sera.

Original languageEnglish (US)
Pages (from-to)581-585
Number of pages5
JournalCancer Immunology, Immunotherapy
Volume61
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

Keywords

  • Antigen
  • Carbohydrates
  • Flow cytometry
  • Interleukin 17
  • Tumor
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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