The energy metabolism of RIF-1 tumours following hydralazine

Zaver M. Bhujwalla, Gillian M. Tozer, Stanley B. Field, Ross J. Maxwell, John R. Grifflths

Research output: Contribution to journalArticlepeer-review

Abstract

Phosphorus-31 Magnetic Resonance Spectroscopy (MRS) was used to observe the effect of two doses of the vasodilator hydralazine on the energy status of RIF-1 tumours. An intravenous dose of 5 mg/kg hydralazine reduced the high energy phosphate metabolites PCr and ATP, lowered pHMRs and raised the levels of inorganic phosphate of tumours within 20 min of administering the drug. The levels of high energy metabolites continued to decrease for at least 24 h. Normal muscle spectra obtained up to 1 h after drug administration remained unchanged. An intravenous dose of 0.5 mg/kg hydralazine also reduced NTP/Pi and PCr/Pi levels of tumours up to at least 5 h after drug administration, but the effect was smaller than for the higher dose. Blood flow measurements and measurements of systemic blood pressure demonstrated that 5 mg/kg of hydralazine produced a reduction in both systemic blood pressure and tumour blood flow relative to most normal tissues investigated. It is concluded that the changes in the P-31 MRS spectra of tumours were due to a reduction in tumour vascular perfusion following administration of hydralazine.

Original languageEnglish (US)
Pages (from-to)281-291
Number of pages11
JournalRadiotherapy and Oncology
Volume19
Issue number3
DOIs
StatePublished - Nov 1990
Externally publishedYes

Keywords

  • Blood flow
  • Blood pressure
  • Energy metabolism
  • Hydralazine
  • P-31 MRS
  • RIF-1 tumour

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'The energy metabolism of RIF-1 tumours following hydralazine'. Together they form a unique fingerprint.

Cite this