The emerging strains of Shigella dysenteriae type 2 in Bangladesh are clonal

Kaisar A. Talukder, B. K. Khajanchi, M. A. Islam, D. K. Dutta, Z. Islam, S. I. Khan, G. B. Nair, D. A. Sack

Research output: Contribution to journalArticle

Abstract

A total of 113 strains of Shigella dysenteriae type 2 isolated from patients attending the Dhaka diarrhoea treatment centre of ICDDR,B: Centre for Health and Population Research during the period 1999-2004 were studied. Serotype of the isolates was confirmed using commercially available antisera. Except for arabinose fermentation, all the strains had similar biochemical reactions. More than 60% of the strains were sensitive to commonly used antibiotics; only 6% (n = 7) of the strains were resistant to nalidixic acid, and none of the strains were resistant to mecillinam and ciprofloxacin. All strains were invasive as demonstrated by the presence of a 140 MDa plasmid, ial, sen and ipaH genes, Congo Red absorption ability and by the Sereny test performed on representative strains. Plasmid patterns were heterogeneous but more than 50% of strains were confined to a single pattern. All strains possessed a 1.6 MDa plasmid and 87% of the strains contained a 4 MDa plasmid. Middle-range plasmids (90 MDa to 30 MDa) present in 36% of the strains were not associated with antibiotic resistance. All the strains were clustered within a single type with four subtypes by pulsed-field gel electrophoresis while ribotyping patterns of all the strains were identical.

Original languageEnglish (US)
Pages (from-to)1249-1256
Number of pages8
JournalEpidemiology and infection
Volume134
Issue number6
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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    Talukder, K. A., Khajanchi, B. K., Islam, M. A., Dutta, D. K., Islam, Z., Khan, S. I., Nair, G. B., & Sack, D. A. (2006). The emerging strains of Shigella dysenteriae type 2 in Bangladesh are clonal. Epidemiology and infection, 134(6), 1249-1256. https://doi.org/10.1017/S0950268806006029