The emerging roles of F-box proteins in pancreatic tumorigenesis

Hua Wang, Anirban Maitra, Huamin Wang

Research output: Contribution to journalArticlepeer-review

Abstract

The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalSeminars in Cancer Biology
Volume36
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • F-box proteins
  • Fbxw7
  • Fbxw8
  • Pancreatic cancer
  • β-TrCP

ASJC Scopus subject areas

  • Cancer Research

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