The emerging roles of atp-dependent chromatin remodeling complexes in pancreatic cancer

Nesrin Hasan, Nita Ahuja

Research output: Contribution to journalReview article

Abstract

Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic dysregulation has been associated with the initiation and progression of pancreatic tumors. Multiple studies have pointed to the involvement of aberrant chromatin modifications in driving tumor behavior. ATP-dependent chromatin remodeling complexes regulate chromatin structure and have critical roles in stem cell maintenance, development, and cancer. Frequent mutations and chromosomal aberrations in the genes associated with subunits of the ATP-dependent chromatin remodeling complexes have been detected in different cancer types. In this review, we summarize the current literature on the genomic alterations and mechanistic studies of the ATP-dependent chromatin remodeling complexes in pancreatic cancer. Our review is focused on the four main subfamilies: SWItch/sucrose non-fermentable (SWI/SNF), imitation SWI (ISWI), chromodomain-helicase DNA-binding protein (CHD), and INOsitol-requiring mutant 80 (INO80). Finally, we discuss potential novel treatment options that use small molecules to target these complexes.

Original languageEnglish (US)
Article number1859
JournalCancers
Volume11
Issue number12
DOIs
StatePublished - Dec 2019
Externally publishedYes

Keywords

  • ATP-dependent chromatin remodeling complexes
  • CHD
  • Chromatin
  • Chromatin remodeling
  • Epigenetics
  • INO80
  • ISWI
  • Pancreas
  • Pancreatic cancer
  • PDAC
  • SWI/SNF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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