Abstract
B cells are traditionally known for their ability to produce antibodies in the context of adaptive immune responses. However, over the last decade B cells have been increasingly recognized as modulators of both adaptive and innate immune responses, as well as players in an important role in the pathogenesis of a variety of human diseases. Here, after briefly summarizing our current understanding of B cell biology, we present a systematic review of the literature from both animal models and human studies that highlight the important role that B lymphocytes play in cardiac and vascular disease. While many aspects of B cell biology in the vasculature and, to an even greater extent, in the heart remain unclear, B cells are emerging as key regulators of cardiovascular adaptation to injury.
Original language | English (US) |
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Pages (from-to) | 99-121 |
Number of pages | 23 |
Journal | Annual review of immunology |
Volume | 38 |
DOIs | |
State | Published - Apr 26 2020 |
Externally published | Yes |
Keywords
- B lymphocyte
- adaptive immunity
- cardiac injury
- heart failure
- innate immunity
- vascular disease
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology