The Emerging Link between Centrosome Aberrations and Metastasis

Gina M. LoMastro, Andrew Holland

Research output: Contribution to journalReview article

Abstract

Centrosome aberrations are commonly observed in human tumors and correlate with tumor aggressiveness. Recent work has shown that centrosome defects facilitate invasion through both cell-autonomous and non-cell-autonomous mechanisms. In this Perspective, LoMastro and Holland discuss how centrosome defects promote invasive behaviors that may contribute to the metastatic cascade.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalDevelopmental Cell
Volume49
Issue number3
DOIs
StatePublished - May 6 2019

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Centrosome
Aberrations
Tumors
Neoplasm Metastasis
Defects
Netherlands
Neoplasms

Keywords

  • aneuploidy
  • cancer
  • centrosomes
  • metastasis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

The Emerging Link between Centrosome Aberrations and Metastasis. / LoMastro, Gina M.; Holland, Andrew.

In: Developmental Cell, Vol. 49, No. 3, 06.05.2019, p. 325-331.

Research output: Contribution to journalReview article

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