The Emerging Link between Centrosome Aberrations and Metastasis

Gina M. LoMastro, Andrew J. Holland

Research output: Contribution to journalReview articlepeer-review


Centrosome aberrations are commonly observed in human tumors and correlate with tumor aggressiveness. Recent work has shown that centrosome defects facilitate invasion through both cell-autonomous and non-cell-autonomous mechanisms. In this Perspective, LoMastro and Holland discuss how centrosome defects promote invasive behaviors that may contribute to the metastatic cascade.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalDevelopmental Cell
Issue number3
StatePublished - May 6 2019


  • aneuploidy
  • cancer
  • centrosomes
  • metastasis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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