Centrosome aberrations are commonly observed in human tumors and correlate with tumor aggressiveness. Recent work has shown that centrosome defects facilitate invasion through both cell-autonomous and non-cell-autonomous mechanisms. In this Perspective, LoMastro and Holland discuss how centrosome defects promote invasive behaviors that may contribute to the metastatic cascade.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology