TY - JOUR
T1 - The elusive Minnie G.
T2 - Revisiting Cushing's case XLV, and his early attempts at improving quality of life
AU - Pendleton, Courtney
AU - Adams, Hadie
AU - Laws, Edward R.
AU - Quinones-Hinojosa, Alfredo
N1 - Funding Information:
Acknowledgments Figures 1, 2a, and 3 provided courtesy of the Alan Mason Chesney Archives. CP supported by a HHMI-Ivy Foundation Research Training Grant. HA supported by VSBfonds and The Prins Bernhard Cultuurfonds. AQH funded by the KO8 NIH grant and an HHMI grant.
PY - 2010/12
Y1 - 2010/12
N2 - Although researchers have discovered that Minnie G. had nearly 50 years of progression-free survival, the absence of her original surgical records have precluded anything more than speculation as to the etiology of her symptoms or the details of her admission. Following IRB approval, and through the courtesy of the Alan Mason Chesney Archives, the microfilm surgical records from the Johns Hopkins Hospital, 1896-1912 were reviewed. Using the surgical number provided in Cushing's publications, the record for Minnie G. was recovered for further review. Cushing's diagnosis relied largely on history and physical findings. Minnie G. presented with stigmata associated with classic Cushings Syndrome: abdominal stria, supraclavicular fat pads, and a rounded face. However, she also presented with unusual physical findings: exophthalmos, and irregular pigmentation of the extremities, face, and eyelids. A note in the chart indicates Minnie G. spoke very little English, implying the history-taking was fraught with opportunities for error. Although there remains no definitive etiology for Minnie G.'s symptoms, this report contributes additional information about her diagnosis and treatment.
AB - Although researchers have discovered that Minnie G. had nearly 50 years of progression-free survival, the absence of her original surgical records have precluded anything more than speculation as to the etiology of her symptoms or the details of her admission. Following IRB approval, and through the courtesy of the Alan Mason Chesney Archives, the microfilm surgical records from the Johns Hopkins Hospital, 1896-1912 were reviewed. Using the surgical number provided in Cushing's publications, the record for Minnie G. was recovered for further review. Cushing's diagnosis relied largely on history and physical findings. Minnie G. presented with stigmata associated with classic Cushings Syndrome: abdominal stria, supraclavicular fat pads, and a rounded face. However, she also presented with unusual physical findings: exophthalmos, and irregular pigmentation of the extremities, face, and eyelids. A note in the chart indicates Minnie G. spoke very little English, implying the history-taking was fraught with opportunities for error. Although there remains no definitive etiology for Minnie G.'s symptoms, this report contributes additional information about her diagnosis and treatment.
KW - Cushing's syndrome
KW - Harvey Cushing
KW - Minnie G.
UR - http://www.scopus.com/inward/record.url?scp=78049293658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049293658&partnerID=8YFLogxK
U2 - 10.1007/s11102-010-0248-1
DO - 10.1007/s11102-010-0248-1
M3 - Article
C2 - 20711851
AN - SCOPUS:78049293658
SN - 1386-341X
VL - 13
SP - 361
EP - 366
JO - Pituitary
JF - Pituitary
IS - 4
ER -