The elongation, termination, and recycling phases of translation in eukaryotes

Thomas E. Dever, Rachel Green

Research output: Contribution to journalArticlepeer-review

Abstract

This work summarizes our current understanding of the elongation and termination/recycling phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In addition to an overview of translation elongation, we discuss unique aspects of eukaryotic translation elongation including eEF1 recycling, eEF2 modification, and eEF3 and eIF5A function. Likewise, we highlight the function of the eukaryotic release factors eRF1 and eRF3 in translation termination, and the functions of ABCE1/Rli1, the Dom34:Hbs1 complex, and Ligatin (eIF2D) in ribosome recycling. Finally, we present some of the key questions in translation elongation, termination, and recycling that remain to be answered.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalCold Spring Harbor Perspectives in Biology
Volume4
Issue number7
DOIs
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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