The efficacy of focal laser treatment in radiation maculopathy

P. G. Hykin, C. L. Shields, J. F. Arevalo, P. De Potter, G. Friere, J. A. Shields

Research output: Contribution to journalArticlepeer-review


Purpose: To determine the efficacy of grid laser therapy for radiation induced maculopathy. Methods: Retrospective chart review of patients with radiation retinopathy following episcleral plaque radiotherapy for choroidal melanoma identified twenty-seven cases with maculopathy managed by grid laser therapy and twenty-five followed without therapy. After exclusion of cases with co-existent cataract, neovascular glaucoma, vitreous haemorrhage and radiation papillopathy, the visual outcome was compared in seventeen treated and eighteen untreated cases. Results: At six months follow-up, visual acuity was unchanged in 13/17 (77%) of treated cases compared to 12/18 (67%) of untreated cases. At twelve months follow up, visual acuity was improved (≥2Snellen lines) in 2/14 treated cases, both with diffuse leakage and minimal macula ischemia and in 0/16 untreated cases. Visual acuity remained stable in 8/14 (57 %) of treated cases and in 5/16 (31%) of untreated cases, (Fischers Exact Test, p<0.26). Conclusions: Grid laser treatment for radiation maculopathy may be effective in occasional cases with diffuse edema and minimal ischemia but there appears to be no significant overall benefit from therapy.

Original languageEnglish (US)
Pages (from-to)S620
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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