The efficacy of DPT and oral poliomyelitis immunization schedules initiated from birth to 12 weeks of age

N. Halsey, A. Galazka

Research output: Contribution to journalReview article

Abstract

Infants should receive live trivalent oral poliovirus vaccine (TOPV) and DPT immunization as early in life as possible in order to minimize the time that they are at risk of contracting these vaccine-preventable diseases. Passively acquired circulating maternal antibodies provide protection in the first few weeks or months of life. Although these antibodies may modify or block the serum immune response during the first few weeks of life, the first or priming dose of DPT can be given effectively after four weeks of age. TOPV administered to infants during the first week of life results in intestinal infections and local immune responses in 50-100% of infants and serum antibody responses in 30-70% of infants. The serum antibody response following TOPV administration at 4-8 weeks of age is as effective as vaccine administered to older infants. The WHO Programme on Immunization recommends initiating DPT and TOPV schedules at 6 weeks of age. In countries where poliomyelitis has not been controlled, TOPV should be given at birth, or at first contact with the health services, than at 6 weeks of age, followed by two additional doses 4 weeks apart.

Original languageEnglish (US)
Pages (from-to)1151-1169
Number of pages19
JournalBulletin of the World Health Organization
Volume63
Issue number6
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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