The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine

K. O. Grosnstad; L. Demagistris; A. Dahlstroum; O. Nilsson; B. Price; M. J. Zinner; B. M. Jaffe; H. Ahlman

doi:10.3109/00365528509089650

The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine

K. O. Grosnstad, L. Demagistris, A. Dahlstroum, O. Nilsson, B. Price, M. J. Zinner, B. M. Jaffe, H. Ahlman

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Endoluminal release of serotonin (5-HT), substance P (SP), and motilin was quantitated after thoracic vagal nerve stimulation in the cat. In duodenum and jejunum, simultaneous release of these compounds was observed. In contrast, vagal stimulation did not augment the rate of luminal secretion of either 5-HT or SP in the distal ileum. Immunohistochemical studies demonstrated 5-HT in both enterochromaffin (EC) cells and nerves throughout the small bowel. However, we were unable to visualize any SP-containing EC cells in the cat, which suggests that the source of luminal SP in this species must be intramural nerves.

Original language	English (US)
Pages (from-to)	163-169
Number of pages	7
Journal	Scandinavian Journal of Gastroenterology
Volume	20
Issue number	2
DOIs	https://doi.org/10.3109/00365528509089650
State	Published - 1985
Externally published	Yes

Keywords

Cat
Duodenum
Endoluminal release
Ileum
Jejunum
Motilin
Radioimmunoassay
Serotonin
Substance P
Vagal nerve stimulation

ASJC Scopus subject areas

Gastroenterology

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10.3109/00365528509089650

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title = "The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine",

abstract = "Endoluminal release of serotonin (5-HT), substance P (SP), and motilin was quantitated after thoracic vagal nerve stimulation in the cat. In duodenum and jejunum, simultaneous release of these compounds was observed. In contrast, vagal stimulation did not augment the rate of luminal secretion of either 5-HT or SP in the distal ileum. Immunohistochemical studies demonstrated 5-HT in both enterochromaffin (EC) cells and nerves throughout the small bowel. However, we were unable to visualize any SP-containing EC cells in the cat, which suggests that the source of luminal SP in this species must be intramural nerves.",

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year = "1985",

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AU - Grosnstad, K. O.

AU - Demagistris, L.

AU - Dahlstroum, A.

AU - Nilsson, O.

AU - Price, B.

AU - Zinner, M. J.

AU - Jaffe, B. M.

AU - Ahlman, H.

PY - 1985

Y1 - 1985

N2 - Endoluminal release of serotonin (5-HT), substance P (SP), and motilin was quantitated after thoracic vagal nerve stimulation in the cat. In duodenum and jejunum, simultaneous release of these compounds was observed. In contrast, vagal stimulation did not augment the rate of luminal secretion of either 5-HT or SP in the distal ileum. Immunohistochemical studies demonstrated 5-HT in both enterochromaffin (EC) cells and nerves throughout the small bowel. However, we were unable to visualize any SP-containing EC cells in the cat, which suggests that the source of luminal SP in this species must be intramural nerves.

AB - Endoluminal release of serotonin (5-HT), substance P (SP), and motilin was quantitated after thoracic vagal nerve stimulation in the cat. In duodenum and jejunum, simultaneous release of these compounds was observed. In contrast, vagal stimulation did not augment the rate of luminal secretion of either 5-HT or SP in the distal ileum. Immunohistochemical studies demonstrated 5-HT in both enterochromaffin (EC) cells and nerves throughout the small bowel. However, we were unable to visualize any SP-containing EC cells in the cat, which suggests that the source of luminal SP in this species must be intramural nerves.

KW - Cat

KW - Duodenum

KW - Endoluminal release

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KW - Jejunum

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KW - Substance P

KW - Vagal nerve stimulation

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The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine

Abstract

Keywords

ASJC Scopus subject areas

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