The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine

K. O. Grosnstad, L. Demagistris, A. Dahlstroum, O. Nilsson, B. Price, M. J. Zinner, B. M. Jaffe, H. Ahlman

Research output: Contribution to journalArticle

Abstract

Endoluminal release of serotonin (5-HT), substance P (SP), and motilin was quantitated after thoracic vagal nerve stimulation in the cat. In duodenum and jejunum, simultaneous release of these compounds was observed. In contrast, vagal stimulation did not augment the rate of luminal secretion of either 5-HT or SP in the distal ileum. Immunohistochemical studies demonstrated 5-HT in both enterochromaffin (EC) cells and nerves throughout the small bowel. However, we were unable to visualize any SP-containing EC cells in the cat, which suggests that the source of luminal SP in this species must be intramural nerves.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume20
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Vagus Nerve Stimulation
Felidae
Substance P
Small Intestine
Serotonin
Enterochromaffin Cells
Cats
Thoracic Nerves
Motilin
Jejunum
Ileum
Duodenum

Keywords

  • Cat
  • Duodenum
  • Endoluminal release
  • Ileum
  • Jejunum
  • Motilin
  • Radioimmunoassay
  • Serotonin
  • Substance P
  • Vagal nerve stimulation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine. / Grosnstad, K. O.; Demagistris, L.; Dahlstroum, A.; Nilsson, O.; Price, B.; Zinner, M. J.; Jaffe, B. M.; Ahlman, H.

In: Scandinavian Journal of Gastroenterology, Vol. 20, No. 2, 1985, p. 163-169.

Research output: Contribution to journalArticle

Grosnstad, KO, Demagistris, L, Dahlstroum, A, Nilsson, O, Price, B, Zinner, MJ, Jaffe, BM & Ahlman, H 1985, 'The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine', Scandinavian Journal of Gastroenterology, vol. 20, no. 2, pp. 163-169. https://doi.org/10.3109/00365528509089650
Grosnstad, K. O. ; Demagistris, L. ; Dahlstroum, A. ; Nilsson, O. ; Price, B. ; Zinner, M. J. ; Jaffe, B. M. ; Ahlman, H. / The effects of vagal nerve stimulation on endoluminal release of serotonin and substance p into the feline small intestine. In: Scandinavian Journal of Gastroenterology. 1985 ; Vol. 20, No. 2. pp. 163-169.
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