The effects of under 6 hours of formalin fixation on hormone receptor and HER2 expression in invasive breast cancer: A systematic review

Shona Kalkman, Maarten W. Barentsz, Paul J. Van Diest

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: A systematic review of the literature was performed to identify whether minimum formalin fixation time may be reduced for reliable immunohistochemical assessment of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Methods: PubMed, EMBASE, and the Cochrane Library were systematically searched for studies addressing effects of brief tissue fixation (

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume142
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Breast cancel
  • Estrogen receptor
  • Fixation time
  • HER2
  • Immunohistochemistry
  • Progesterone receptor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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