The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney

Karen A. Munger, Thomas M. Coffman, Robert C. Griffiths, Agnes Foco, Kamal F. Badr

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Abstract

The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney are examined. Kidneys were transplanted from Munich-Wistar (MW) rats to syngeneic controls and MHC-incompatible PVG strain recipients. We report on 4 groups of animals: (1) two-kidney control MW rats; (2) unilaterally nephrectomized MW rats (UNX); (3) renal transplantation from MHC-identical MW littermates and removal of native kidneys (SYN); and (4) transplantation from MW donors to MHC-incompatible PVG rats and removal of native kidneys (ALLO). Glomerular filtration rate (GFR), single-nephron (SN)GFR, and glomerular capillary pressure (PGC) in SYN kidneys were depressed as compared to those in UNX (GFR, 1.41±0.08 vs. 0.80±0.08 ml/min; SNGFR, 67.2±4.8 vs. 44.7±6.6 nl/min; and PGC, 67±2 vs. 48±4 mmHg, UNX vs. SYN, respectively, P10 dyn±sec±cm5; SYN, 1.37±0.36 1010 dyn ± sec ± cm-6; ALLO, 4.76±0.74 1010 dyn ± sec ± cm-5 [PGC in the nonrejecting transplanted kidney, which may relate to as yet unidentified. consequences of the transplant surgery. More significantly, the principal mechanism leading to the reduced GFR characteristic of acute allograft rejection is identified as severe preglomerular vasoconstriction.

Original languageEnglish (US)
Pages (from-to)1219-1224
Number of pages6
JournalTransplantation
Volume55
Issue number6
StatePublished - 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Munger, K. A., Coffman, T. M., Griffiths, R. C., Foco, A., & Badr, K. F. (1993). The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney. Transplantation, 55(6), 1219-1224.