TY - JOUR
T1 - The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney
AU - Munger, Karen A.
AU - Coffman, Thomas M.
AU - Griffiths, Robert C.
AU - Foco, Agnes
AU - Badr, Kamal F.
PY - 1993
Y1 - 1993
N2 - The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney are examined. Kidneys were transplanted from Munich-Wistar (MW) rats to syngeneic controls and MHC-incompatible PVG strain recipients. We report on 4 groups of animals: (1) two-kidney control MW rats; (2) unilaterally nephrectomized MW rats (UNX); (3) renal transplantation from MHC-identical MW littermates and removal of native kidneys (SYN); and (4) transplantation from MW donors to MHC-incompatible PVG rats and removal of native kidneys (ALLO). Glomerular filtration rate (GFR), single-nephron (SN)GFR, and glomerular capillary pressure (PGC) in SYN kidneys were depressed as compared to those in UNX (GFR, 1.41±0.08 vs. 0.80±0.08 ml/min; SNGFR, 67.2±4.8 vs. 44.7±6.6 nl/min; and PGC, 67±2 vs. 48±4 mmHg, UNX vs. SYN, respectively, P10 dyn±sec±cm5; SYN, 1.37±0.36 1010 dyn ± sec ± cm-6; ALLO, 4.76±0.74 1010 dyn ± sec ± cm-5 [PGC in the nonrejecting transplanted kidney, which may relate to as yet unidentified. consequences of the transplant surgery. More significantly, the principal mechanism leading to the reduced GFR characteristic of acute allograft rejection is identified as severe preglomerular vasoconstriction.
AB - The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney are examined. Kidneys were transplanted from Munich-Wistar (MW) rats to syngeneic controls and MHC-incompatible PVG strain recipients. We report on 4 groups of animals: (1) two-kidney control MW rats; (2) unilaterally nephrectomized MW rats (UNX); (3) renal transplantation from MHC-identical MW littermates and removal of native kidneys (SYN); and (4) transplantation from MW donors to MHC-incompatible PVG rats and removal of native kidneys (ALLO). Glomerular filtration rate (GFR), single-nephron (SN)GFR, and glomerular capillary pressure (PGC) in SYN kidneys were depressed as compared to those in UNX (GFR, 1.41±0.08 vs. 0.80±0.08 ml/min; SNGFR, 67.2±4.8 vs. 44.7±6.6 nl/min; and PGC, 67±2 vs. 48±4 mmHg, UNX vs. SYN, respectively, P10 dyn±sec±cm5; SYN, 1.37±0.36 1010 dyn ± sec ± cm-6; ALLO, 4.76±0.74 1010 dyn ± sec ± cm-5 [PGC in the nonrejecting transplanted kidney, which may relate to as yet unidentified. consequences of the transplant surgery. More significantly, the principal mechanism leading to the reduced GFR characteristic of acute allograft rejection is identified as severe preglomerular vasoconstriction.
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M3 - Article
C2 - 8516805
AN - SCOPUS:0027235697
SN - 0041-1337
VL - 55
SP - 1219
EP - 1224
JO - Transplantation
JF - Transplantation
IS - 6
ER -