The effects of sleep on median nerve short latency somatosensory evoked potentials

R. O. Addy, D. S. Dinner, H. Lüders, R. P. Lesser, H. H. Morris, E. Wyllie

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of sleep on median nerve short latency somatosensory evoked potentials were studied in 7 subjects made up of 6 patients being evaluated for seizure disorders by all-night electroencephalograms and 1 normal healthy volunteer. The median nerve was stimulated at the wrist, and the peripheral (N9), subcortical (P13) and early cortical (N1, P2) evoked potentials were recorded during full wakefulness and natural night-time sleep. Sleep-wake state was monitored by the simultaneously obtained polysomnogram. The latencies of the cortical responses were prolonged during non-rapid eye movement (NREM) sleep. In 3 of the subjects P2 was consistently bifid during NREM sleep only. The second component of the bifid potential, 3-4 msec longer in latency than the first, appeared to be selectively enhanced during NREM sleep whereas the first component tended to become less prominent or even disappear. This suggests that the 2 peaks have different generators that are affected differently by NREM sleep. These are clinically relevant findings for interpretation of routine clinical studies.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology/ Evoked Potentials
Volume74
Issue number2
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Keywords

  • Sleep
  • Somatosensory evoked potentials (SSEPs)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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