The effects of placental malaria on mother-to-child HIV transmission in Rakai, Uganda

Heena Brahmbhatt, Godfrey Kigozi, Fred Wabwire-Mangen, David Serwadda, Nelson Sewankambo, Tom Lutalo, Maria J. Wawer, Carlos Abramowsky, David Sullivan, Ronald Gray

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the association of placental malaria and mother-to-child transmission (MTCT) of HIV in a prospective community-randomized trial in Rakai District, Uganda. In the 746 HIV-positive mother-infant pairs, the MTCT rate was 20.4%. Placental malaria was more common in HIV-positive than HIV-negative women. After multivariate adjustment for HIV viral load, the risk of MTCT associated with placental malaria was 2.89 and with HIV viral load the risk was 2.85. Interventions to prevent malaria during pregnancy could potentially reduce MTCT.

Original languageEnglish (US)
Pages (from-to)2539-2541
Number of pages3
JournalAIDS
Volume17
Issue number17
DOIs
StatePublished - Nov 21 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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