The effects of phencyclidine and ketamine on sensory thresholds and reaction times in the baboon

Scott E. Lukas, Robert D. Hienz, Joseph V. Brady

Research output: Contribution to journalArticle

Abstract

Adult male baboons were trained on a reaction time procedure, and absolute thresholds and reaction times to both a 16.0 kHz pure tone and a white light were obtained. Acute IM injections of phencyclidine (0.0032 to 0.1 mg/kg) or ketamine (0.032 to 3.2 mg/kg) were given at the beginning of 2-hr test sessions. Phencyclidine had no effect on auditory thresholds, or visual reaction times, but selectively elevated auditory reaction times. Ketamine, on the other hand, elevated auditory thresholds and both auditory and visual reaction times, while having no effect on visual thresholds. Ketamine was also less potent than phencyclidine in elevating auditory reaction times, and recovery from these impairments was evident during the two-hour test sessions for ketamine, but not for phencyclidine.

Original languageEnglish (US)
Pages (from-to)743-747
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume23
Issue number5
DOIs
StatePublished - Nov 1985

Keywords

  • Baboons
  • Hearing
  • Ketamine
  • PCP
  • Phencyclidine
  • Primates
  • Psychophysics
  • Vision

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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