The effects of ozone on immune function

G. J. Jakab, Ernst W Spannhake, Brendan J Canning, S. R. Kleeberger, M. I. Gilmour

Research output: Contribution to journalArticle

Abstract

A review of the literature reveals that ozone (O3) exposure can either suppress or enhance immune responsiveness. These disparate effects elicited by O3 exposure depend, in large part, on the experimental design used, the immune parameters examined as well as the animal species studied. Despite the apparent contradictions, a general pattern of response to O3 exposure can be recognized. Most studies indicate that continuous O3 exposure leads to an early (days 0-3) impairment of immune responsiveness followed, with continued exposures, by a form of adaptation to O3 that results in a reestablishment of the immune response. The effects of O3 exposure on the response to antigenic stimulation also depend on the time at which O3 exposure occurred. Whereas O3 exposure prior to immunization is without effect on the response to antigen, O3 exposure subsequent to immunization suppresses the response to antigen. Although most studies have focused on immune responses in the lung, numerous investigators have provided functional and anatomical evidence to support the hypothesis that O3 exposure can have profound effects on systemic immunity.

Original languageEnglish (US)
Pages (from-to)77-89
Number of pages13
JournalEnvironmental Health Perspectives
Volume103
Issue numberSUPPL. 2
StatePublished - 1995

Fingerprint

Immunization
Ozone
ozone
Antigens
Design of experiments
Immunity
Animals
Research Design
Research Personnel
Lung
immunization
antigen
immune response
exposure
effect
immunity
experimental design

Keywords

  • Alveolar macrophages
  • Immunity
  • Immunoglobulins
  • Lymphocytes
  • Mitogenesis
  • Ozone
  • Peritoneal macrophages
  • Phagocytosis
  • Prostaglandins
  • Respiratory infections

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Jakab, G. J., Spannhake, E. W., Canning, B. J., Kleeberger, S. R., & Gilmour, M. I. (1995). The effects of ozone on immune function. Environmental Health Perspectives, 103(SUPPL. 2), 77-89.

The effects of ozone on immune function. / Jakab, G. J.; Spannhake, Ernst W; Canning, Brendan J; Kleeberger, S. R.; Gilmour, M. I.

In: Environmental Health Perspectives, Vol. 103, No. SUPPL. 2, 1995, p. 77-89.

Research output: Contribution to journalArticle

Jakab, GJ, Spannhake, EW, Canning, BJ, Kleeberger, SR & Gilmour, MI 1995, 'The effects of ozone on immune function', Environmental Health Perspectives, vol. 103, no. SUPPL. 2, pp. 77-89.
Jakab GJ, Spannhake EW, Canning BJ, Kleeberger SR, Gilmour MI. The effects of ozone on immune function. Environmental Health Perspectives. 1995;103(SUPPL. 2):77-89.
Jakab, G. J. ; Spannhake, Ernst W ; Canning, Brendan J ; Kleeberger, S. R. ; Gilmour, M. I. / The effects of ozone on immune function. In: Environmental Health Perspectives. 1995 ; Vol. 103, No. SUPPL. 2. pp. 77-89.
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