The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles

Jeffrey S. Orringer, Craig Hammerberg, Lori Lowe, Sewon Kang, Timothy M. Johnson, Ted Hamilton, John J. Voorhees, Gary J. Fisher

Research output: Contribution to journalArticle

Abstract

Background: The mechanisms involved in laser-mediated hair removal remain unclear. One means of reducing hair growth is alteration of follicular stem cells. Objective: We sought to examine the effects of laser hair removal on the immunohistochemical staining properties of human hair follicles, including the putative stem cells of the bulge region. Methods: Treatment of unwanted axillary hair was performed on one side using an 800 nm-wavelength diode laser and on the other side using a 1064 nm-wavelength neodymium:yttrium-aluminum-garnet laser. Serial skin samples were obtained at baseline and various times after treatment and stained using immunohistochemical techniques. Results: Hair shafts were thermally altered, but the immunostaining properties of much of the follicle, including the bulge region, remained generally unchanged. Limitations: This study only addressed the acute immunohistochemical changes found after a single treatment using specific laser parameters. Conclusions: Laser-mediated hair removal does not appear to work by frank destruction of follicular stem cells. Other mechanisms including functional alteration of these cells may underlie the clinical efficacy of the procedure.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume55
Issue number3
DOIs
StatePublished - Sep 2006
Externally publishedYes

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Hair Removal
Hair Follicle
Lasers
Hair
Staining and Labeling
Stem Cells
Neodymium
Semiconductor Lasers
Solid-State Lasers
Therapeutics
Skin
Growth

ASJC Scopus subject areas

  • Dermatology

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The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles. / Orringer, Jeffrey S.; Hammerberg, Craig; Lowe, Lori; Kang, Sewon; Johnson, Timothy M.; Hamilton, Ted; Voorhees, John J.; Fisher, Gary J.

In: Journal of the American Academy of Dermatology, Vol. 55, No. 3, 09.2006, p. 402-407.

Research output: Contribution to journalArticle

Orringer, Jeffrey S. ; Hammerberg, Craig ; Lowe, Lori ; Kang, Sewon ; Johnson, Timothy M. ; Hamilton, Ted ; Voorhees, John J. ; Fisher, Gary J. / The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles. In: Journal of the American Academy of Dermatology. 2006 ; Vol. 55, No. 3. pp. 402-407.
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AU - Hammerberg, Craig

AU - Lowe, Lori

AU - Kang, Sewon

AU - Johnson, Timothy M.

AU - Hamilton, Ted

AU - Voorhees, John J.

AU - Fisher, Gary J.

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N2 - Background: The mechanisms involved in laser-mediated hair removal remain unclear. One means of reducing hair growth is alteration of follicular stem cells. Objective: We sought to examine the effects of laser hair removal on the immunohistochemical staining properties of human hair follicles, including the putative stem cells of the bulge region. Methods: Treatment of unwanted axillary hair was performed on one side using an 800 nm-wavelength diode laser and on the other side using a 1064 nm-wavelength neodymium:yttrium-aluminum-garnet laser. Serial skin samples were obtained at baseline and various times after treatment and stained using immunohistochemical techniques. Results: Hair shafts were thermally altered, but the immunostaining properties of much of the follicle, including the bulge region, remained generally unchanged. Limitations: This study only addressed the acute immunohistochemical changes found after a single treatment using specific laser parameters. Conclusions: Laser-mediated hair removal does not appear to work by frank destruction of follicular stem cells. Other mechanisms including functional alteration of these cells may underlie the clinical efficacy of the procedure.

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