The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar

Katarzyna Kordas, Emily H. Siegel, Deanna K. Olney, Joanne Katz, James M. Tielsch, Patricia K. Kariger, Sabra S. Khalfan, Steven C. Leclerq, Subarna K. Khatry, Rebecca J. Stoltzfus

Research output: Contribution to journalArticle

Abstract

BACKGROUND: There is some evidence that sleep patterns may be affected by iron deficiency anemia but the role of iron in sleep has not been tested in a randomized iron supplementation trial. OBJECTIVE: We investigated the effect of iron supplementation on maternal reports of sleep in infants in 2 randomized, placebo-controlled trials from Pemba Island, Zanzibar, and Nepal. DESIGN: In both studies, which had parallel designs and were carried out in years 2002 to 2003, infants received iron-folic acid with or without zinc daily for 12 months, and assessments of development were made every 3 months for the duration of the study. Eight hundred seventy-seven Pemban (12.5 ± 4.0 months old) and 567 Nepali (10.8 ± 4.0 months) infants participated. Maternal reports of sleep patterns (napping frequency and duration, nighttime sleep duration, frequency of night waking) were collected. RESULTS: Mean Hb concentration was 9.2 ± 1.1 for Pemban and 10.1 ± 1.2 g/dL for Nepali infants. Approximately, one-third of the children were stunted. Supplemental iron was consistently associated with longer night and total sleep duration. The effects of zinc supplementation also included longer sleep duration. CONCLUSIONS: Micronutrient supplementation in infants at high risk for iron deficiency and iron deficiency anemia was related to increased night sleep duration and less night waking.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalJournal of Developmental and Behavioral Pediatrics
Volume30
Issue number2
DOIs
StatePublished - Apr 2009

Fingerprint

Nepal
Tanzania
Zinc
Sleep
Iron
Mothers
Iron-Deficiency Anemias
Indian Ocean Islands
Micronutrients
Folic Acid
Islands
Randomized Controlled Trials
Placebos

Keywords

  • Developing countries
  • Infants
  • Iron deficiency anemia
  • Iron supplementation
  • Sleep

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar. / Kordas, Katarzyna; Siegel, Emily H.; Olney, Deanna K.; Katz, Joanne; Tielsch, James M.; Kariger, Patricia K.; Khalfan, Sabra S.; Leclerq, Steven C.; Khatry, Subarna K.; Stoltzfus, Rebecca J.

In: Journal of Developmental and Behavioral Pediatrics, Vol. 30, No. 2, 04.2009, p. 131-139.

Research output: Contribution to journalArticle

Kordas, K, Siegel, EH, Olney, DK, Katz, J, Tielsch, JM, Kariger, PK, Khalfan, SS, Leclerq, SC, Khatry, SK & Stoltzfus, RJ 2009, 'The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar', Journal of Developmental and Behavioral Pediatrics, vol. 30, no. 2, pp. 131-139. https://doi.org/10.1097/DBP.0b013e31819e6a48
Kordas, Katarzyna ; Siegel, Emily H. ; Olney, Deanna K. ; Katz, Joanne ; Tielsch, James M. ; Kariger, Patricia K. ; Khalfan, Sabra S. ; Leclerq, Steven C. ; Khatry, Subarna K. ; Stoltzfus, Rebecca J. / The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar. In: Journal of Developmental and Behavioral Pediatrics. 2009 ; Vol. 30, No. 2. pp. 131-139.
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