The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women

M. N. Harvie, M. Pegington, M. P. Mattson, J. Frystyk, B. Dillon, G. Evans, J. Cuzick, S. A. Jebb, B. Martin, R. G. Cutler, T. G. Son, S. Maudsley, O. D. Carlson, J. M. Egan, A. Flyvbjerg, A. Howell

Research output: Contribution to journalArticle

Abstract

Background: The problems of adherence to energy restriction in humans are well known.Objective: To compare the feasibility and effectiveness of intermittent continuous energy (IER) with continuous energy restriction (CER) for weight loss, insulin sensitivity and other metabolic disease risk markers.Design: Randomized comparison of a 25% energy restriction as IER (∼2710 kJ/day for 2 days/week) or CER (∼6276 kJ/day for 7 days/week) in 107 overweight or obese (mean (±s.d.) body mass index 30.6 (±5.1) kg m-2) premenopausal women observed over a period of 6 months. Weight, anthropometry, biomarkers for breast cancer, diabetes, cardiovascular disease and dementia risk; insulin resistance (HOMA), oxidative stress markers, leptin, adiponectin, insulin-like growth factor (IGF)-1 and IGF binding proteins 1 and 2, androgens, prolactin, inflammatory markers (high sensitivity C-reactive protein and sialic acid), lipids, blood pressure and brain-derived neurotrophic factor were assessed at baseline and after 1, 3 and 6 months.Results: Last observation carried forward analysis showed that IER and CER are equally effective for weight loss: mean (95% confidence interval) weight change for IER was -6.4 (-7.9 to -4.8) kg vs -5.6 (-6.9 to -4.4) kg for CER (P-value for difference between groups = 0.4). Both groups experienced comparable reductions in leptin, free androgen index, high-sensitivity C-reactive protein, total and LDL cholesterol, triglycerides, blood pressure and increases in sex hormone binding globulin, IGF binding proteins 1 and 2. Reductions in fasting insulin and insulin resistance were modest in both groups, but greater with IER than with CER; difference between groups for fasting insulin was -1.2 (-1.4 to -1.0)μU ml-1 and for insulin resistance was -1.2 (-1.5 to -1.0)μU mmol-1l-1 (both P=0.04).Conclusion: IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk.

Original languageEnglish (US)
Pages (from-to)714-727
Number of pages14
JournalInternational Journal of Obesity
Volume35
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

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Metabolic Diseases
Insulin Resistance
Weight Loss
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 1
Leptin
C-Reactive Protein
Androgens
Fasting
Biomarkers
Insulin
Blood Pressure
Weights and Measures
Sex Hormone-Binding Globulin
Anthropometry
Adiponectin
Brain-Derived Neurotrophic Factor
N-Acetylneuraminic Acid
Somatomedins
Prolactin

Keywords

  • continuous energy restriction
  • insulin sensitivity
  • intermittent
  • premenopausal women
  • randomized

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers : A randomized trial in young overweight women. / Harvie, M. N.; Pegington, M.; Mattson, M. P.; Frystyk, J.; Dillon, B.; Evans, G.; Cuzick, J.; Jebb, S. A.; Martin, B.; Cutler, R. G.; Son, T. G.; Maudsley, S.; Carlson, O. D.; Egan, J. M.; Flyvbjerg, A.; Howell, A.

In: International Journal of Obesity, Vol. 35, No. 5, 05.2011, p. 714-727.

Research output: Contribution to journalArticle

Harvie, MN, Pegington, M, Mattson, MP, Frystyk, J, Dillon, B, Evans, G, Cuzick, J, Jebb, SA, Martin, B, Cutler, RG, Son, TG, Maudsley, S, Carlson, OD, Egan, JM, Flyvbjerg, A & Howell, A 2011, 'The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women', International Journal of Obesity, vol. 35, no. 5, pp. 714-727. https://doi.org/10.1038/ijo.2010.171
Harvie, M. N. ; Pegington, M. ; Mattson, M. P. ; Frystyk, J. ; Dillon, B. ; Evans, G. ; Cuzick, J. ; Jebb, S. A. ; Martin, B. ; Cutler, R. G. ; Son, T. G. ; Maudsley, S. ; Carlson, O. D. ; Egan, J. M. ; Flyvbjerg, A. ; Howell, A. / The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers : A randomized trial in young overweight women. In: International Journal of Obesity. 2011 ; Vol. 35, No. 5. pp. 714-727.
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T2 - A randomized trial in young overweight women

AU - Harvie, M. N.

AU - Pegington, M.

AU - Mattson, M. P.

AU - Frystyk, J.

AU - Dillon, B.

AU - Evans, G.

AU - Cuzick, J.

AU - Jebb, S. A.

AU - Martin, B.

AU - Cutler, R. G.

AU - Son, T. G.

AU - Maudsley, S.

AU - Carlson, O. D.

AU - Egan, J. M.

AU - Flyvbjerg, A.

AU - Howell, A.

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N2 - Background: The problems of adherence to energy restriction in humans are well known.Objective: To compare the feasibility and effectiveness of intermittent continuous energy (IER) with continuous energy restriction (CER) for weight loss, insulin sensitivity and other metabolic disease risk markers.Design: Randomized comparison of a 25% energy restriction as IER (∼2710 kJ/day for 2 days/week) or CER (∼6276 kJ/day for 7 days/week) in 107 overweight or obese (mean (±s.d.) body mass index 30.6 (±5.1) kg m-2) premenopausal women observed over a period of 6 months. Weight, anthropometry, biomarkers for breast cancer, diabetes, cardiovascular disease and dementia risk; insulin resistance (HOMA), oxidative stress markers, leptin, adiponectin, insulin-like growth factor (IGF)-1 and IGF binding proteins 1 and 2, androgens, prolactin, inflammatory markers (high sensitivity C-reactive protein and sialic acid), lipids, blood pressure and brain-derived neurotrophic factor were assessed at baseline and after 1, 3 and 6 months.Results: Last observation carried forward analysis showed that IER and CER are equally effective for weight loss: mean (95% confidence interval) weight change for IER was -6.4 (-7.9 to -4.8) kg vs -5.6 (-6.9 to -4.4) kg for CER (P-value for difference between groups = 0.4). Both groups experienced comparable reductions in leptin, free androgen index, high-sensitivity C-reactive protein, total and LDL cholesterol, triglycerides, blood pressure and increases in sex hormone binding globulin, IGF binding proteins 1 and 2. Reductions in fasting insulin and insulin resistance were modest in both groups, but greater with IER than with CER; difference between groups for fasting insulin was -1.2 (-1.4 to -1.0)μU ml-1 and for insulin resistance was -1.2 (-1.5 to -1.0)μU mmol-1l-1 (both P=0.04).Conclusion: IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk.

AB - Background: The problems of adherence to energy restriction in humans are well known.Objective: To compare the feasibility and effectiveness of intermittent continuous energy (IER) with continuous energy restriction (CER) for weight loss, insulin sensitivity and other metabolic disease risk markers.Design: Randomized comparison of a 25% energy restriction as IER (∼2710 kJ/day for 2 days/week) or CER (∼6276 kJ/day for 7 days/week) in 107 overweight or obese (mean (±s.d.) body mass index 30.6 (±5.1) kg m-2) premenopausal women observed over a period of 6 months. Weight, anthropometry, biomarkers for breast cancer, diabetes, cardiovascular disease and dementia risk; insulin resistance (HOMA), oxidative stress markers, leptin, adiponectin, insulin-like growth factor (IGF)-1 and IGF binding proteins 1 and 2, androgens, prolactin, inflammatory markers (high sensitivity C-reactive protein and sialic acid), lipids, blood pressure and brain-derived neurotrophic factor were assessed at baseline and after 1, 3 and 6 months.Results: Last observation carried forward analysis showed that IER and CER are equally effective for weight loss: mean (95% confidence interval) weight change for IER was -6.4 (-7.9 to -4.8) kg vs -5.6 (-6.9 to -4.4) kg for CER (P-value for difference between groups = 0.4). Both groups experienced comparable reductions in leptin, free androgen index, high-sensitivity C-reactive protein, total and LDL cholesterol, triglycerides, blood pressure and increases in sex hormone binding globulin, IGF binding proteins 1 and 2. Reductions in fasting insulin and insulin resistance were modest in both groups, but greater with IER than with CER; difference between groups for fasting insulin was -1.2 (-1.4 to -1.0)μU ml-1 and for insulin resistance was -1.2 (-1.5 to -1.0)μU mmol-1l-1 (both P=0.04).Conclusion: IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk.

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KW - insulin sensitivity

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KW - randomized

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