The effects of illicit drug use and HIV infection on sex hormone levels in women

Joseph Cofrancesco; Nina Shah; Khalil Ghanem; Adrian Dobs; Robert Klein; Kenneth Mayer; Paula Schuman; David Vlahov; Anne Rompalo

doi:10.1080/09513590600687603

The effects of illicit drug use and HIV infection on sex hormone levels in women

Joseph Cofrancesco, Nina Shah, Khalil Ghanem, Adrian Dobs, Robert Klein, Kenneth Mayer, Paula Schuman, David Vlahov, Anne Rompalo

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Drug use and HIV infection may affect sex hormone levels in women. One hundred and ninety-six women with and without a history of illicit drug use (50 HIV-negative and 148 HIV-infected), with regular menses, who never used antiretrovirals, were evaluated. Luteinizing hormone levels were significantly higher in women with a CD4 cell count p p = 0.03) and higher levels of prolactin ( p = 0.002); mean estradiol levels were 43% lower in women who used intravenous drugs (p < 0.001). Alcohol and crack cocaine use was not associated with sex hormone levels. Age, race, body mass index and degree of HIV immunosuppression were also associated with differences in sex hormone levels.

Original language	English (US)
Pages (from-to)	244-251
Number of pages	8
Journal	Gynecological Endocrinology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1080/09513590600687603
State	Published - May 1 2006

Keywords

AIDS
HIV
Injection drug use
Sex hormones
Testosterone

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Obstetrics and Gynecology

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10.1080/09513590600687603

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title = "The effects of illicit drug use and HIV infection on sex hormone levels in women",

abstract = "Drug use and HIV infection may affect sex hormone levels in women. One hundred and ninety-six women with and without a history of illicit drug use (50 HIV-negative and 148 HIV-infected), with regular menses, who never used antiretrovirals, were evaluated. Luteinizing hormone levels were significantly higher in women with a CD4 cell count p p = 0.03) and higher levels of prolactin ( p = 0.002); mean estradiol levels were 43% lower in women who used intravenous drugs (p < 0.001). Alcohol and crack cocaine use was not associated with sex hormone levels. Age, race, body mass index and degree of HIV immunosuppression were also associated with differences in sex hormone levels.",

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author = "Joseph Cofrancesco and Nina Shah and Khalil Ghanem and Adrian Dobs and Robert Klein and Kenneth Mayer and Paula Schuman and David Vlahov and Anne Rompalo",

note = "Funding Information: The work was supported by cooperative agreements # U64\CCU106795, U64\CCU206798, U64\ CCU306802 and U64\CCU506831 with the Centers for Disease Control and Prevention, including supplementary support from the National Institute on Drug Abuse.",

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AU - Cofrancesco, Joseph

AU - Shah, Nina

AU - Ghanem, Khalil

AU - Dobs, Adrian

AU - Klein, Robert

AU - Mayer, Kenneth

AU - Schuman, Paula

AU - Vlahov, David

AU - Rompalo, Anne

N1 - Funding Information: The work was supported by cooperative agreements # U64\CCU106795, U64\CCU206798, U64\ CCU306802 and U64\CCU506831 with the Centers for Disease Control and Prevention, including supplementary support from the National Institute on Drug Abuse.

PY - 2006/5/1

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N2 - Drug use and HIV infection may affect sex hormone levels in women. One hundred and ninety-six women with and without a history of illicit drug use (50 HIV-negative and 148 HIV-infected), with regular menses, who never used antiretrovirals, were evaluated. Luteinizing hormone levels were significantly higher in women with a CD4 cell count p p = 0.03) and higher levels of prolactin ( p = 0.002); mean estradiol levels were 43% lower in women who used intravenous drugs (p < 0.001). Alcohol and crack cocaine use was not associated with sex hormone levels. Age, race, body mass index and degree of HIV immunosuppression were also associated with differences in sex hormone levels.

AB - Drug use and HIV infection may affect sex hormone levels in women. One hundred and ninety-six women with and without a history of illicit drug use (50 HIV-negative and 148 HIV-infected), with regular menses, who never used antiretrovirals, were evaluated. Luteinizing hormone levels were significantly higher in women with a CD4 cell count p p = 0.03) and higher levels of prolactin ( p = 0.002); mean estradiol levels were 43% lower in women who used intravenous drugs (p < 0.001). Alcohol and crack cocaine use was not associated with sex hormone levels. Age, race, body mass index and degree of HIV immunosuppression were also associated with differences in sex hormone levels.

KW - AIDS

KW - HIV

KW - Injection drug use

KW - Sex hormones

KW - Testosterone

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The effects of illicit drug use and HIV infection on sex hormone levels in women

Abstract

Keywords

ASJC Scopus subject areas

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