The effects of hyperglycemia on skin graft survival in the burn patient

A. Mowlavi, K. Andrews, S. Milner, D. N. Herndon, J. P. Heggers

Research output: Contribution to journalArticle

Abstract

The authors elected to determine the relative effects of hyperglycemia and/or elevated wound Gram-positive bacterial counts on success of skin graft survival in 74 burn patients. Results of serum glucose and quantitative wound biopsies on the day of admission and on postoperative day 4 were charted. Cases were separated into the following groups for analysis: normoglycemia plus normal bacterial counts, elevated bacterial counts only, hyperglycemia only, and hyperglycemia plus elevated bacterial counts. Successful graft 'take' was defined as survival of 80% to 100% of the grafted area as assessed on postoperative day 4. Significant results included decreased incidence of graft take for groups with hyperglycemia only (62.5%), elevated bacterial counts only (63.3%), as well as hyperglycemia plus elevated bacterial counts (54.5%) when compared with the group with normoglycemia plus normal bacterial counts (92.8%; p = 0.020, p = 0.042, p = 0.012 respectively) for physiological parameters measured on postoperative day 4 only. Additionally, incidence of graft take was reassessed and found to be decreased significantly in groups with hyperglycemia (60.0%) vs. groups with normoglycemia (84.6%), regardless of Gram-positive bacterial counts (p = 0.034).

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalAnnals of Plastic Surgery
Volume45
Issue number6
StatePublished - 2000
Externally publishedYes

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Bacterial Load
Graft Survival
Hyperglycemia
Skin
Transplants
Incidence
Wounds and Injuries
Biopsy
Glucose
Survival
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Mowlavi, A., Andrews, K., Milner, S., Herndon, D. N., & Heggers, J. P. (2000). The effects of hyperglycemia on skin graft survival in the burn patient. Annals of Plastic Surgery, 45(6), 629-632.

The effects of hyperglycemia on skin graft survival in the burn patient. / Mowlavi, A.; Andrews, K.; Milner, S.; Herndon, D. N.; Heggers, J. P.

In: Annals of Plastic Surgery, Vol. 45, No. 6, 2000, p. 629-632.

Research output: Contribution to journalArticle

Mowlavi, A, Andrews, K, Milner, S, Herndon, DN & Heggers, JP 2000, 'The effects of hyperglycemia on skin graft survival in the burn patient', Annals of Plastic Surgery, vol. 45, no. 6, pp. 629-632.
Mowlavi A, Andrews K, Milner S, Herndon DN, Heggers JP. The effects of hyperglycemia on skin graft survival in the burn patient. Annals of Plastic Surgery. 2000;45(6):629-632.
Mowlavi, A. ; Andrews, K. ; Milner, S. ; Herndon, D. N. ; Heggers, J. P. / The effects of hyperglycemia on skin graft survival in the burn patient. In: Annals of Plastic Surgery. 2000 ; Vol. 45, No. 6. pp. 629-632.
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