The Effects of Hyperbaric Oxygen on Free Flaps in Rats

Carolyn M. Kaelin; Michael J. Im; Roy A.M. Myers; Paul N. Manson; John E. Hoopes

doi:10.1001/archsurg.1990.01410170053011

The Effects of Hyperbaric Oxygen on Free Flaps in Rats

Carolyn M. Kaelin, Michael J. Im, Roy A.M. Myers, Paul N. Manson, John E. Hoopes

School of Medicine

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The effects of hyperbaric oxygen on survival were investigated in free flaps and island flaps. Skin flaps transplanted following 18,21, and 24 hours of preservation at 24°C demonstrated survival rates of 20%, 10%, and 0%, respectively. Treatment with hyperbaric 100% oxygen improved the survival rates to 66%, 67%, and 40%. A preservation time of 21 to 24 hours at room temperature appears to be the threshold of irreversible ischemic damage. In acute island flaps, flap survival was improved significantly from 35% to 53% and 64% of the random flap area by preoperative or postoperative treatment, respectively. Prolonged preoperative and postoperative treatment improved survival to 66%.

Original language	English (US)
Pages (from-to)	607-609
Number of pages	3
Journal	Archives of surgery
Volume	125
Issue number	5
DOIs	https://doi.org/10.1001/archsurg.1990.01410170053011
State	Published - May 1990

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1990.01410170053011

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title = "The Effects of Hyperbaric Oxygen on Free Flaps in Rats",

abstract = "The effects of hyperbaric oxygen on survival were investigated in free flaps and island flaps. Skin flaps transplanted following 18,21, and 24 hours of preservation at 24°C demonstrated survival rates of 20%, 10%, and 0%, respectively. Treatment with hyperbaric 100% oxygen improved the survival rates to 66%, 67%, and 40%. A preservation time of 21 to 24 hours at room temperature appears to be the threshold of irreversible ischemic damage. In acute island flaps, flap survival was improved significantly from 35% to 53% and 64% of the random flap area by preoperative or postoperative treatment, respectively. Prolonged preoperative and postoperative treatment improved survival to 66%.",

author = "Kaelin, {Carolyn M.} and Im, {Michael J.} and Myers, {Roy A.M.} and Manson, {Paul N.} and Hoopes, {John E.}",

year = "1990",

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AU - Hoopes, John E.

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N2 - The effects of hyperbaric oxygen on survival were investigated in free flaps and island flaps. Skin flaps transplanted following 18,21, and 24 hours of preservation at 24°C demonstrated survival rates of 20%, 10%, and 0%, respectively. Treatment with hyperbaric 100% oxygen improved the survival rates to 66%, 67%, and 40%. A preservation time of 21 to 24 hours at room temperature appears to be the threshold of irreversible ischemic damage. In acute island flaps, flap survival was improved significantly from 35% to 53% and 64% of the random flap area by preoperative or postoperative treatment, respectively. Prolonged preoperative and postoperative treatment improved survival to 66%.

AB - The effects of hyperbaric oxygen on survival were investigated in free flaps and island flaps. Skin flaps transplanted following 18,21, and 24 hours of preservation at 24°C demonstrated survival rates of 20%, 10%, and 0%, respectively. Treatment with hyperbaric 100% oxygen improved the survival rates to 66%, 67%, and 40%. A preservation time of 21 to 24 hours at room temperature appears to be the threshold of irreversible ischemic damage. In acute island flaps, flap survival was improved significantly from 35% to 53% and 64% of the random flap area by preoperative or postoperative treatment, respectively. Prolonged preoperative and postoperative treatment improved survival to 66%.

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The Effects of Hyperbaric Oxygen on Free Flaps in Rats

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