The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men

S. Mitchell Harman, Marc R. Blackman

Research output: Contribution to journalArticle

Abstract

Decreases in growth hormone (GH) and insulin-like growth factor I occur with age, in addition to oestrogen deficiency in women and a reduction in the levels of testosterone in men. These age-related hormonal changes may contribute to reductions in lean body mass, muscle strength and cardiac endurance, which can be partially reversed in elderly people with GH treatment, and testosterone supplements and oestrogen/progestin hormone replacement therapy in men and women, respectively. These treatments are, however, thought to have potentially serious adverse effects. We conducted a study to evaluate the separate and interactive effects of GH and sex steroids on body composition, muscle strength and cardiac endurance as well as the rate of adverse events in healthy elderly people. The results of the study showed that although there were beneficial effects with GH and sex steroid treatment, a high percentage of adverse effects occurred after 26 weeks of treatment, demonstrating a need for more research on the safety of hormonal therapy in the elderly population.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalHormone Research
Volume60
Issue numberSUPPL. 1
DOIs
StatePublished - 2003

Fingerprint

Muscle Strength
Growth Hormone
Fats
Steroids
Testosterone
Therapeutics
Estrogen Replacement Therapy
Hormone Replacement Therapy
Body Composition
Insulin-Like Growth Factor I
Estrogens
Safety
Research
Population

Keywords

  • Adverse events
  • Elderly population
  • Fat mass
  • Growth hormone
  • Lean body mass
  • Oestrogen
  • Sex hormones
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology

Cite this

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abstract = "Decreases in growth hormone (GH) and insulin-like growth factor I occur with age, in addition to oestrogen deficiency in women and a reduction in the levels of testosterone in men. These age-related hormonal changes may contribute to reductions in lean body mass, muscle strength and cardiac endurance, which can be partially reversed in elderly people with GH treatment, and testosterone supplements and oestrogen/progestin hormone replacement therapy in men and women, respectively. These treatments are, however, thought to have potentially serious adverse effects. We conducted a study to evaluate the separate and interactive effects of GH and sex steroids on body composition, muscle strength and cardiac endurance as well as the rate of adverse events in healthy elderly people. The results of the study showed that although there were beneficial effects with GH and sex steroid treatment, a high percentage of adverse effects occurred after 26 weeks of treatment, demonstrating a need for more research on the safety of hormonal therapy in the elderly population.",
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