Abstract
Objective: The primary objective of this study was to characterize the association between cyclic alternating pattern (CAP) and neurocognitive performance in a group of normal subjects before and after two nights of experimentally-induced sleep fragmentation. Subjects and methods: Fifteen healthy subjects underwent one night of uninterrupted and two sequential nights of experimental sleep fragmentation achieved by auditory and mechanical stimuli. Eight subjects were re-examined using a similar paradigm with three nights of uninterrupted sleep. Sleep was polygraphically recorded and CAP analysis was performed for all recordings. A battery of neurocognitive tests was performed for spatial attention, inhibition of return, mental rotation, and Stroop color word test in the afternoon following the first and third night of sleep under fragmented and non-fragmented conditions. Results: With sleep fragmentation, the percentage of slow-wave sleep was dramatically reduced and there was a twofold increase in total CAP rate across all NREM sleep stages. Moreover, the number of all CAP A subtypes/hour of sleep (index) was significantly increased. Total CAP rate during the non-fragmented night correlated with reaction times. Similarly, the percentages of A1 and A3 subtypes were negatively and positively correlated with reaction times, respectively. Of the neurocognitive test battery, however, only values obtained from some subtests of the mental rotation test showed a significant improvement after sleep fragmentation. Conclusions: The results of this study suggest that CAP A1 subtypes are associated with higher cognitive functioning, whereas CAP A3 subtypes are associated with lower cognitive functioning in young healthy subjects. The lack of cognitive functioning impairment after sleep fragmentation may be due to persistence and even enhancement of transient slow-wave activity contained in CAP A1 subtypes which also caused a significant enhancement of the EEG power spectrum in the lower frequencies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 378-385 |
| Number of pages | 8 |
| Journal | Sleep Medicine |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2010 |
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Keywords
- Arousals
- Cyclic alternating pattern
- Neurocognitive function
- Sleep fragmentation
- Sleep instability
- Slow-wave sleep
ASJC Scopus subject areas
- Medicine(all)
Cite this
The effects of experimental sleep fragmentation on cognitive processing. / Ferri, Raffaele; Drago, Valeria; Aricò, Debora; Bruni, Oliviero; Remington, Roger W.; Stamatakis, Katherine; Punjabi, Naresh M.
In: Sleep Medicine, Vol. 11, No. 4, 04.2010, p. 378-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of experimental sleep fragmentation on cognitive processing
AU - Ferri, Raffaele
AU - Drago, Valeria
AU - Aricò, Debora
AU - Bruni, Oliviero
AU - Remington, Roger W.
AU - Stamatakis, Katherine
AU - Punjabi, Naresh M
PY - 2010/4
Y1 - 2010/4
N2 - Objective: The primary objective of this study was to characterize the association between cyclic alternating pattern (CAP) and neurocognitive performance in a group of normal subjects before and after two nights of experimentally-induced sleep fragmentation. Subjects and methods: Fifteen healthy subjects underwent one night of uninterrupted and two sequential nights of experimental sleep fragmentation achieved by auditory and mechanical stimuli. Eight subjects were re-examined using a similar paradigm with three nights of uninterrupted sleep. Sleep was polygraphically recorded and CAP analysis was performed for all recordings. A battery of neurocognitive tests was performed for spatial attention, inhibition of return, mental rotation, and Stroop color word test in the afternoon following the first and third night of sleep under fragmented and non-fragmented conditions. Results: With sleep fragmentation, the percentage of slow-wave sleep was dramatically reduced and there was a twofold increase in total CAP rate across all NREM sleep stages. Moreover, the number of all CAP A subtypes/hour of sleep (index) was significantly increased. Total CAP rate during the non-fragmented night correlated with reaction times. Similarly, the percentages of A1 and A3 subtypes were negatively and positively correlated with reaction times, respectively. Of the neurocognitive test battery, however, only values obtained from some subtests of the mental rotation test showed a significant improvement after sleep fragmentation. Conclusions: The results of this study suggest that CAP A1 subtypes are associated with higher cognitive functioning, whereas CAP A3 subtypes are associated with lower cognitive functioning in young healthy subjects. The lack of cognitive functioning impairment after sleep fragmentation may be due to persistence and even enhancement of transient slow-wave activity contained in CAP A1 subtypes which also caused a significant enhancement of the EEG power spectrum in the lower frequencies.
AB - Objective: The primary objective of this study was to characterize the association between cyclic alternating pattern (CAP) and neurocognitive performance in a group of normal subjects before and after two nights of experimentally-induced sleep fragmentation. Subjects and methods: Fifteen healthy subjects underwent one night of uninterrupted and two sequential nights of experimental sleep fragmentation achieved by auditory and mechanical stimuli. Eight subjects were re-examined using a similar paradigm with three nights of uninterrupted sleep. Sleep was polygraphically recorded and CAP analysis was performed for all recordings. A battery of neurocognitive tests was performed for spatial attention, inhibition of return, mental rotation, and Stroop color word test in the afternoon following the first and third night of sleep under fragmented and non-fragmented conditions. Results: With sleep fragmentation, the percentage of slow-wave sleep was dramatically reduced and there was a twofold increase in total CAP rate across all NREM sleep stages. Moreover, the number of all CAP A subtypes/hour of sleep (index) was significantly increased. Total CAP rate during the non-fragmented night correlated with reaction times. Similarly, the percentages of A1 and A3 subtypes were negatively and positively correlated with reaction times, respectively. Of the neurocognitive test battery, however, only values obtained from some subtests of the mental rotation test showed a significant improvement after sleep fragmentation. Conclusions: The results of this study suggest that CAP A1 subtypes are associated with higher cognitive functioning, whereas CAP A3 subtypes are associated with lower cognitive functioning in young healthy subjects. The lack of cognitive functioning impairment after sleep fragmentation may be due to persistence and even enhancement of transient slow-wave activity contained in CAP A1 subtypes which also caused a significant enhancement of the EEG power spectrum in the lower frequencies.
KW - Arousals
KW - Cyclic alternating pattern
KW - Neurocognitive function
KW - Sleep fragmentation
KW - Sleep instability
KW - Slow-wave sleep
UR - http://www.scopus.com/inward/record.url?scp=77949912390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949912390&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2010.01.006
DO - 10.1016/j.sleep.2010.01.006
M3 - Article
VL - 11
SP - 378
EP - 385
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 4
ER -