The effects of D-penicillamine and daunorubicin on conjunctival fibroblast proliferation and collagen synthesis

L. J.B. McGuigan, H. A. Quigley, G. Lutty, C. Enger, E. Young

Research output: Contribution to journalArticlepeer-review

Abstract

Two drugs, D-penicillamine and daunorubicin, were tested for their effect on proliferation and collagen synthesis of cultured conjunctival fibroblasts. This cell type is likely responsible for scar formation and ultimate filter surgery failure in glaucoma patients. Both drugs were antiproliferative; however, D-penicillamine required 2000 times the concentration of daunorubicin to achieve a similar degree of inhibition. D-penicillamine had a more consistent effect on intracellular collagen synthesis than daunorubicin at the doses tested. In contrast, at concentrations of daunorubicin where all proliferation ceased, intracellular production and extracellular transport of collagen were maintained.

Original languageEnglish (US)
Pages (from-to)112-118
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume29
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'The effects of D-penicillamine and daunorubicin on conjunctival fibroblast proliferation and collagen synthesis'. Together they form a unique fingerprint.

Cite this