The effects of d-amphetamine and diazepam on schedule-induced defecation in rats

Mark LeSage, Malath Makhay, Iser DeLeon, Alan Poling

Research output: Contribution to journalArticle

Abstract

The effects of d-amphetamine (0.32 to 5.6 mg/kg) and diazepam (0.10 to 5.6 mg/kg) on defecation were examined in two groups of rats. One group was exposed to a fixed-time 60-s (FT 60-s) schedule of food delivery and the other group was exposed to massed-food sessions. During vehicle control sessions, rats exposed to the FT 60-s schedule excreted a significantly higher number of fecal boli than rats exposed to massed-food sessions. d-Amphetamine, at doses above 0.56 mg/kg, significantly reduced defecation (boli produced) in both groups, although the magnitude of the drug's effect was larger in the group exposed to the FT 60-s schedule. For both groups, diazepam only produced a significant decrease in defecation at the highest dose (5.6 mg/kg). These results appear to be inconsistent with interpretations of adjunctive behavior that emphasize arousal or emotion as mechanisms.

Original languageEnglish (US)
Pages (from-to)787-790
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume48
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • d-Amphetamine
  • Diazepam
  • Rats
  • Schedule-induced defection

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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