Clozapine has proved effective in alleviating a wide range of psychiatric symptoms in schizophrenia. Its effects on cognitive function in schizophrenia are more variable. Clozapine appears to have a salutary effect on some aspects of attention, response speed, and fluency, whereas it appears to have a mild but adverse effect on visual memory and some executive functions. This profile may be related to the affinity of clozapine for dopaminergic type I and muscarinic receptors and relative lack of affinity for dopaminergic type II receptors.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Clinical Psychiatry|
|Issue number||9 SUPPL. B|
|State||Published - Nov 16 1994|
ASJC Scopus subject areas
- Psychiatry and Mental health