The effects of autologous platelet gel on wound healing

Jenifer L. Henderson, Michael A. Keefe, Craig L. Cupp, Derin C. Wester, E. Victor Ross, Timothy Hannon, Paul Shick, Devin McConnell

Research output: Contribution to journalArticle

Abstract

Laser resurfacing techniques have become a popular means of achieving rejuvenation of damaged skin. Interest is great in attempting to speed re-epithelialization and healing so that patients can return to their normal activities as quickly as possible. Previous studies have demonstrated that wounds heal more quickly when they are covered and kept moist than when they are left open to the air. Until now, no study has been conducted to investigate whether the healing process of a superficial skin burn might be accelerated by the use of an autologous platelet gel as a biologic dressing. Our study of five pigs showed that autologous platelet gel can influence wound healing by stimulating an intense inflammatory process that leads to highly significant increases in the production of extracellular matrices and granulation tissue. The platelet gel accelerated vascular ingrowth, increased fibroblastic proliferation, and accelerated collagen production. However, the gel did not appear to accelerate re-epithelialization. The aggressive production of granulation tissue and the acceleration of collagen production might mean that autologous platelet gel will have a future role in the treatment of burns because the highly vascularized bed it helps create should promote the success of skin grafting in patients with deep partial-thickness and full-thickness burns.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalEar, nose, & throat journal
Volume82
Issue number8
StatePublished - Aug 1 2003
Externally publishedYes

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Wound Healing
Blood Platelets
Gels
Re-Epithelialization
Granulation Tissue
Burns
Biological Dressings
Collagen
Rejuvenation
Skin
Skin Transplantation
Extracellular Matrix
Blood Vessels
Lasers
Swine
Air
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Henderson, J. L., Keefe, M. A., Cupp, C. L., Wester, D. C., Ross, E. V., Hannon, T., ... McConnell, D. (2003). The effects of autologous platelet gel on wound healing. Ear, nose, & throat journal, 82(8), 598-602.

The effects of autologous platelet gel on wound healing. / Henderson, Jenifer L.; Keefe, Michael A.; Cupp, Craig L.; Wester, Derin C.; Ross, E. Victor; Hannon, Timothy; Shick, Paul; McConnell, Devin.

In: Ear, nose, & throat journal, Vol. 82, No. 8, 01.08.2003, p. 598-602.

Research output: Contribution to journalArticle

Henderson, JL, Keefe, MA, Cupp, CL, Wester, DC, Ross, EV, Hannon, T, Shick, P & McConnell, D 2003, 'The effects of autologous platelet gel on wound healing', Ear, nose, & throat journal, vol. 82, no. 8, pp. 598-602.
Henderson JL, Keefe MA, Cupp CL, Wester DC, Ross EV, Hannon T et al. The effects of autologous platelet gel on wound healing. Ear, nose, & throat journal. 2003 Aug 1;82(8):598-602.
Henderson, Jenifer L. ; Keefe, Michael A. ; Cupp, Craig L. ; Wester, Derin C. ; Ross, E. Victor ; Hannon, Timothy ; Shick, Paul ; McConnell, Devin. / The effects of autologous platelet gel on wound healing. In: Ear, nose, & throat journal. 2003 ; Vol. 82, No. 8. pp. 598-602.
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