The effectiveness of interventions on incubation of AIDS as measured by secular increases within a population

Donald R. Hoover; Alvaro Muñtoz; Yanhua He; Jeremy M.G. Taylor; Lawrence Kingsley; Joan S. Chmiel; Alfred Saah

doi:10.1002/sim.4780131920

The effectiveness of interventions on incubation of AIDS as measured by secular increases within a population

Donald R. Hoover, Alvaro Muñtoz, Yanhua He, Jeremy M.G. Taylor, Lawrence Kingsley, Joan S. Chmiel, Alfred Saah

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Methods are developed to estimate and test for the impact of intervention use on a population's survival function (time to AIDS). Each participant's history is divided into J + 1 components: Ω_o occurring before the intervention is available and Ω₁ to Ω_J occurring later, as the intervention becomes successively more available. Distribution free truncated Kaplan‐Meier models based on time since exposure fit separately to the risk sets/outcomes in Ω_o to Ω_J directly show the changing patterns of survival. Multivariate proportional hazards models can be used to adjust for covariates. Application of these methods indicates that availability of proven anti‐AIDS interventions may have delayed time to AIDS by 8 months in an educated HIV‐1 infected homosexual cohort with good access to medical care.

Original language	English (US)
Pages (from-to)	2127-2139
Number of pages	13
Journal	Statistics in Medicine
Volume	13
Issue number	19-20
DOIs	https://doi.org/10.1002/sim.4780131920
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Statistics and Probability

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abstract = "Methods are developed to estimate and test for the impact of intervention use on a population's survival function (time to AIDS). Each participant's history is divided into J + 1 components: Ωo occurring before the intervention is available and Ω1 to ΩJ occurring later, as the intervention becomes successively more available. Distribution free truncated Kaplan‐Meier models based on time since exposure fit separately to the risk sets/outcomes in Ωo to ΩJ directly show the changing patterns of survival. Multivariate proportional hazards models can be used to adjust for covariates. Application of these methods indicates that availability of proven anti‐AIDS interventions may have delayed time to AIDS by 8 months in an educated HIV‐1 infected homosexual cohort with good access to medical care.",

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AU - Kingsley, Lawrence

AU - Chmiel, Joan S.

AU - Saah, Alfred

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AB - Methods are developed to estimate and test for the impact of intervention use on a population's survival function (time to AIDS). Each participant's history is divided into J + 1 components: Ωo occurring before the intervention is available and Ω1 to ΩJ occurring later, as the intervention becomes successively more available. Distribution free truncated Kaplan‐Meier models based on time since exposure fit separately to the risk sets/outcomes in Ωo to ΩJ directly show the changing patterns of survival. Multivariate proportional hazards models can be used to adjust for covariates. Application of these methods indicates that availability of proven anti‐AIDS interventions may have delayed time to AIDS by 8 months in an educated HIV‐1 infected homosexual cohort with good access to medical care.

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The effectiveness of interventions on incubation of AIDS as measured by secular increases within a population

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