A series of experiments upon calves combining various types of anastomotic precedures on the pulmonary artery with hilar stripping of the left lung and contralateral pulmonary artery ligation are described. Hilar stripping alone combined with contralateral pulmonary artery ligation caused severe pulmonary hypertension and death in four of five animals. Division of the left pulmonary artery and reconstruction by an angioplastic procedure decreased the degree of pulmonary hypertension but had no effect on the animals' ability to survive. Reconstruction of the pulmonary artery with a metal cannula coated with a nonclotting surface also caused severe pulmonary hypertension and death of four of five calves operated upon. Histologic sections of the lungs of those animals dying in the immediate post-operative period were compatible with heart failure secondary to the pulmonary hypertension.
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