The effect of uvb irradiation on proliferative activity and cell growth potential of cord blood

Jonathan I. Greenfeld, France Noizat Pirenne, Mark A. Hardy, Soji F. Oluwole, Charles A. Hesdorffer, Robert A. Preti, Donat De Groote, Paul Franchimont

Research output: Contribution to journalArticle

Abstract

To determine the degree of graft versus host disease (GVHD) prophylaxis that might be necessary if cord blood (CB) transplantation is more widely applied, we compared human cord blood mononuclear cell (CBMC) and adult peripheral blood mononuclear cell (PBMC) proliferative responses and stimulatory capabilities; to examine the utility of UVB irradiation for GVHD prophylaxis, we compared proliferative responses, antigen-presenting cell (APC) stimulatory functions, and cytokine production by untreated and UVB-irradiated CBMCs. The two cell types, CBMC and PBMC, proliferated equally both in response to phytohemagglutinin (PHA) and alloantigen in mixed lymphocyte culture (MLC). Cord blood stimulatory function in MLC was significantly (P

Original languageEnglish (US)
Pages (from-to)504-510
Number of pages7
JournalTransplantation
Volume58
Issue number4
StatePublished - Aug 27 1994
Externally publishedYes

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Fetal Blood
Blood Cells
Graft vs Host Disease
Growth
Lymphocytes
Isoantigens
Phytohemagglutinins
Antigen-Presenting Cells
Transplantation
Cytokines

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Greenfeld, J. I., Noizat Pirenne, F., Hardy, M. A., Oluwole, S. F., Hesdorffer, C. A., Preti, R. A., ... Franchimont, P. (1994). The effect of uvb irradiation on proliferative activity and cell growth potential of cord blood. Transplantation, 58(4), 504-510.

The effect of uvb irradiation on proliferative activity and cell growth potential of cord blood. / Greenfeld, Jonathan I.; Noizat Pirenne, France; Hardy, Mark A.; Oluwole, Soji F.; Hesdorffer, Charles A.; Preti, Robert A.; De Groote, Donat; Franchimont, Paul.

In: Transplantation, Vol. 58, No. 4, 27.08.1994, p. 504-510.

Research output: Contribution to journalArticle

Greenfeld, JI, Noizat Pirenne, F, Hardy, MA, Oluwole, SF, Hesdorffer, CA, Preti, RA, De Groote, D & Franchimont, P 1994, 'The effect of uvb irradiation on proliferative activity and cell growth potential of cord blood', Transplantation, vol. 58, no. 4, pp. 504-510.
Greenfeld JI, Noizat Pirenne F, Hardy MA, Oluwole SF, Hesdorffer CA, Preti RA et al. The effect of uvb irradiation on proliferative activity and cell growth potential of cord blood. Transplantation. 1994 Aug 27;58(4):504-510.
Greenfeld, Jonathan I. ; Noizat Pirenne, France ; Hardy, Mark A. ; Oluwole, Soji F. ; Hesdorffer, Charles A. ; Preti, Robert A. ; De Groote, Donat ; Franchimont, Paul. / The effect of uvb irradiation on proliferative activity and cell growth potential of cord blood. In: Transplantation. 1994 ; Vol. 58, No. 4. pp. 504-510.
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