The effect of treatment on survival in patients with advanced laryngeal carcinoma

Christine Gourin, Bryant T. Conger, W. Chris Sheils, Paul A. Bilodeau, Teresa A. Coleman, Edward S. Porubsky

Research output: Contribution to journalArticle

Abstract

Objectives/Hypothesis: Over the last 2 decades, survival from laryngeal cancer has decreased. We sought to identify factors associated with decreased survival in laryngeal cancer. Methods: Patients diagnosed with laryngeal squamous cell carcinoma from 1985 to 2002 were retrospectively reviewed. Results: A total of 451 patients met study criteria. Five-year survival rates were 85% for stage I., 77% for stage II, 51% for stage III, and 35% for stage IV disease. Survival for patients with stage I-III disease was similar for patients treated operatively or nonoperatively (P=.4). However, patients with stage III disease treated nonoperatively had worse survival with radiation alone (XRT) compared to chemoradiation (CR) (P=.006). Patients with stage IV disease had significantly better survival with surgery (49%) than CR (21%) or XRT alone (14%) (P

Original languageEnglish (US)
Pages (from-to)1312-1317
Number of pages6
JournalLaryngoscope
Volume119
Issue number7
DOIs
StatePublished - Jul 2009

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Carcinoma
Survival
Laryngeal Neoplasms
Therapeutics
Squamous Cell Carcinoma
Survival Rate
Radiation

Keywords

  • Chemoradiation
  • Head and neck neoplasms
  • Larynx
  • Radiation
  • Squamous cell cancer
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Gourin, C., Conger, B. T., Sheils, W. C., Bilodeau, P. A., Coleman, T. A., & Porubsky, E. S. (2009). The effect of treatment on survival in patients with advanced laryngeal carcinoma. Laryngoscope, 119(7), 1312-1317. https://doi.org/10.1002/lary.20477

The effect of treatment on survival in patients with advanced laryngeal carcinoma. / Gourin, Christine; Conger, Bryant T.; Sheils, W. Chris; Bilodeau, Paul A.; Coleman, Teresa A.; Porubsky, Edward S.

In: Laryngoscope, Vol. 119, No. 7, 07.2009, p. 1312-1317.

Research output: Contribution to journalArticle

Gourin, C, Conger, BT, Sheils, WC, Bilodeau, PA, Coleman, TA & Porubsky, ES 2009, 'The effect of treatment on survival in patients with advanced laryngeal carcinoma', Laryngoscope, vol. 119, no. 7, pp. 1312-1317. https://doi.org/10.1002/lary.20477
Gourin C, Conger BT, Sheils WC, Bilodeau PA, Coleman TA, Porubsky ES. The effect of treatment on survival in patients with advanced laryngeal carcinoma. Laryngoscope. 2009 Jul;119(7):1312-1317. https://doi.org/10.1002/lary.20477
Gourin, Christine ; Conger, Bryant T. ; Sheils, W. Chris ; Bilodeau, Paul A. ; Coleman, Teresa A. ; Porubsky, Edward S. / The effect of treatment on survival in patients with advanced laryngeal carcinoma. In: Laryngoscope. 2009 ; Vol. 119, No. 7. pp. 1312-1317.
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