The effect of testosterone and cyproterone acetate on the concentration of γ-aminobutyric acid in brain areas of aggressive and non-aggressive mice

Christopher J. Earley, B. E. Leonard

Research output: Contribution to journalArticlepeer-review

Abstract

Mice which had been housed in groups were introduced into the home cages of isolated mice and the aggressive defensive behaviour assessed. The grouped mice were chronically treated with testosterone, cyproterone acetate or arachis oil. The concentration of GABA was determined in 10 regions following the last behavioural assessment. The grouped mice which were treated with testosterone or with the anti-androgen, cyproteroneacetate, were subjected to fewer aggressive attacks by the isolated mice than the grouped controls. The concentration of GABA in particular brain areas appears to depend on the degree of aggressive behaviour exhibited, the type of environment into which the mouse is introduced, the hormone treatment, and the housing conditions.

Original languageEnglish (US)
Pages (from-to)409-413
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume6
Issue number4
DOIs
StatePublished - Apr 1977
Externally publishedYes

Keywords

  • Aggression
  • Brain
  • Cyproterone acetate
  • GABA
  • Testosterone

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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