The effect of taste stimuli on histamine release in the anterior hypothalamus of rats

Yada Treesukosol, Tomoko Ishizuka, Takashi Yamamoto, Atsushi Yamatodani

Research output: Contribution to journalArticle

Abstract

We studied the effect of gustatory stimulation on hypothalamic histamine release. Administering a four-basic taste mixture significantly increased histamine release, but not in the chorda tympani-transected rats. 0.1 M NaCl significantly increased histamine release, whereas 0.5 M sucrose, 0.02 M quinine HCl and 0.01 M HCl had no effect. However, when the concentration of HCl was increased to 0.03 M, a significant increase in histamine release was seen. These results suggest that taste information via the chorda tympani activates the histaminergic system.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalBrain research
Volume964
Issue number1
DOIs
StatePublished - Feb 21 2003

Keywords

  • Anterior hypothalamus
  • Chorda tympani
  • Histamine
  • Microdialysis
  • Taste

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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