The effect of somatostatin on central hemodynamics, renal blood flow, and renal function in dogs

B. A. Price, B. M. Jaffe, M. J. Zinner

Research output: Contribution to journalArticle

Abstract

We investigated the effects of infusion of somatostatin (200 and 500 ng/kg/min) on central hemodynamics and renal blood flow measured with radioactive microspheres. At the lower dose infusion rate somatostatin did not alter any hemodynamic parameter, but at 500 ng/kg/min somatostatin caused minor transient bradycardia, lowered cardiac output, and increased peripheral resistance. Both infusions inhibited renal arterial flow, with decreases noted in both cortical and medullary components. The 20% fall in renal perfusion was confirmed by the hippurate clearance technique, and there was a corresponding 17% decrease in the glomerular filtration rate. In contrast, no changes were noted in urine output, urinary concentrations of sodium or potassium, or urine osmolarity. These hemodynamic and renal side effects might limit the therapeutic usefulness of somatostatin infusion.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalSurgery
Volume97
Issue number3
StatePublished - 1985
Externally publishedYes

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Renal Circulation
Somatostatin
Hemodynamics
Dogs
Kidney
Urine
Bradycardia
Glomerular Filtration Rate
Microspheres
Cardiac Output
Vascular Resistance
Osmolar Concentration
Potassium
Perfusion
Sodium
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Price, B. A., Jaffe, B. M., & Zinner, M. J. (1985). The effect of somatostatin on central hemodynamics, renal blood flow, and renal function in dogs. Surgery, 97(3), 285-289.

The effect of somatostatin on central hemodynamics, renal blood flow, and renal function in dogs. / Price, B. A.; Jaffe, B. M.; Zinner, M. J.

In: Surgery, Vol. 97, No. 3, 1985, p. 285-289.

Research output: Contribution to journalArticle

Price, BA, Jaffe, BM & Zinner, MJ 1985, 'The effect of somatostatin on central hemodynamics, renal blood flow, and renal function in dogs', Surgery, vol. 97, no. 3, pp. 285-289.
Price, B. A. ; Jaffe, B. M. ; Zinner, M. J. / The effect of somatostatin on central hemodynamics, renal blood flow, and renal function in dogs. In: Surgery. 1985 ; Vol. 97, No. 3. pp. 285-289.
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