The effect of signal variability on the histograms of anthropomorphic channel outputs: Factors resulting in non-normally distributed data

Fatma E.A. Elshahaby, Michael Ghaly, Abhinav K. Jha, Eric C. Frey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Model Observers are widely used in medical imaging for the optimization and evaluation of instrumentation, acquisition parameters and image reconstruction and processing methods. The channelized Hotelling observer (CHO) is a commonly used model observer in nuclear medicine and has seen increasing use in other modalities. An anthropmorphic CHO consists of a set of channels that model some aspects of the human visual system and the Hotelling Observer, which is the optimal linear discriminant. The optimality of the CHO is based on the assumption that the channel outputs for data with and without the signal present have a multivariate normal distribution with equal class covariance matrices. The channel outputs result from the dot product of channel templates with input images and are thus the sum of a large number of random variables. The central limit theorem is thus often used to justify the assumption that the channel outputs are normally distributed. In this work, we aim to examine this assumption for realistically simulated nuclear medicine images when various types of signal variability are present.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationImage Perception, Observer Performance, and Technology Assessment
EditorsClaudia R. Mello-Thoms, Matthew A. Kupinski, Claudia R. Mello-Thoms
PublisherSPIE
ISBN (Electronic)9781628415063
DOIs
StatePublished - Jan 1 2015
EventMedical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment - Orlando, United States
Duration: Feb 25 2015Feb 26 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9416
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment
CountryUnited States
CityOrlando
Period2/25/152/26/15

Keywords

  • Channelized Hotelling Observer (CHO)
  • Image Quality
  • Model Observer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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