The effect of seizure focus on regional language processing areas

Elizabeth S. Duke, Mekdem Tesfaye, Madison M. Berl, Jennifer E. Walker, Eva Katharina Ritzl, Rebecca E. Fasano, Joan A. Conry, Phillip L. Pearl, Sususmu Sato, William H. Theodore, William D. Gaillard

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the effect of seizure focus location within the left hemisphere on the expression of regional language dominance. Methods: In this cross-sectional study we investigated 90 patients (mean age 23.3 ± 12.9 years) with left hemisphere focal epilepsy (mean age onset 11.7 ± 8.3 years). Eighteen patients had a frontal lobe focus and 72 had a temporal lobe focus (43 mesial; 29 neocortical). Subjects performed an auditory word definition language paradigm using 3 Tesla blood oxygen level dependent (BOLD) EPI functional magnetic resonance imaging (fMRI). Data were analyzed in SPM2. Regional laterality indices (LIs) for inferior frontal gyrus (IFG), and Wernicke's area (WA), were calculated using a bootstrap method. Categorical language dominance and mean LI were analyzed. Key Findings: Mean WA LI was lower for subjects with a mesial temporal focus compared with a frontal focus (p = 0.04). There was a greater proportion of atypical language in WA for subjects with a mesial temporal focus compared with a frontal focus (π2 = 4.37, p = 0.04). WA LI did not differ for subjects with a neocortical focus compared with a mesial focus or a frontal focus. Mean IFG LI and proportion of atypical language in IFG were similar across seizure focus groups. Age and age of onset were not correlated with mean laterality in WA or IFG. Epilepsy duration tended to be negatively correlated with WA LI (r = -0.18, p = 0.10), but not IFG LI. Significance: Temporal lobe foci have wide-ranging effects on the distributed language system. In contrast, the effects of a frontal lobe focus appear restricted to anterior rather than posterior language processing areas.

Original languageEnglish (US)
Pages (from-to)1044-1050
Number of pages7
JournalEpilepsia
Volume53
Issue number6
DOIs
StatePublished - 2012

Fingerprint

Seizures
Language
Prefrontal Cortex
Frontal Lobe
Temporal Lobe
Age of Onset
Computer Communication Networks
Partial Epilepsy
Focus Groups
Wernicke Area
Epilepsy
Cross-Sectional Studies
Magnetic Resonance Imaging
Oxygen

Keywords

  • Childhood epilepsy
  • Language dominance
  • Reorganization

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Duke, E. S., Tesfaye, M., Berl, M. M., Walker, J. E., Ritzl, E. K., Fasano, R. E., ... Gaillard, W. D. (2012). The effect of seizure focus on regional language processing areas. Epilepsia, 53(6), 1044-1050. https://doi.org/10.1111/j.1528-1167.2012.03490.x

The effect of seizure focus on regional language processing areas. / Duke, Elizabeth S.; Tesfaye, Mekdem; Berl, Madison M.; Walker, Jennifer E.; Ritzl, Eva Katharina; Fasano, Rebecca E.; Conry, Joan A.; Pearl, Phillip L.; Sato, Sususmu; Theodore, William H.; Gaillard, William D.

In: Epilepsia, Vol. 53, No. 6, 2012, p. 1044-1050.

Research output: Contribution to journalArticle

Duke, ES, Tesfaye, M, Berl, MM, Walker, JE, Ritzl, EK, Fasano, RE, Conry, JA, Pearl, PL, Sato, S, Theodore, WH & Gaillard, WD 2012, 'The effect of seizure focus on regional language processing areas', Epilepsia, vol. 53, no. 6, pp. 1044-1050. https://doi.org/10.1111/j.1528-1167.2012.03490.x
Duke, Elizabeth S. ; Tesfaye, Mekdem ; Berl, Madison M. ; Walker, Jennifer E. ; Ritzl, Eva Katharina ; Fasano, Rebecca E. ; Conry, Joan A. ; Pearl, Phillip L. ; Sato, Sususmu ; Theodore, William H. ; Gaillard, William D. / The effect of seizure focus on regional language processing areas. In: Epilepsia. 2012 ; Vol. 53, No. 6. pp. 1044-1050.
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AU - Walker, Jennifer E.

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AU - Fasano, Rebecca E.

AU - Conry, Joan A.

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