TY - GEN
T1 - The effect of round window reinforcement on human hearing
AU - Guan, Xiying
AU - Cheng, Y. Song
AU - Galaiya, Deepa
AU - Nakajima, Hideko H.
N1 - Funding Information:
We are grateful for the contributions of John Rosowski, Diane Jones, Melissa McKinnon, Mike Ravicz, Jean Phillips, and the staff of the Otolaryngology Department and Eaton-Peabody Laboratory at Massachusetts Eye and Ear. This work is supported by NIDCD/NIH R01 DC013303 and Hearing Health Foundation Emerging Research Grant 2016.
Publisher Copyright:
© 2018 Author(s).
PY - 2018/5/31
Y1 - 2018/5/31
N2 - The compliant round window (RW) allows volume velocity to flow within the incompressible fluid of the cochlea as the oval window vibrates during sound stimulation. Recently, surgically stiffened RW is emerging as a treatment for various conditions such as superior canal dehiscence and hyperacusis. However, we lack the basic understanding of how reinforcing the RW affects sound transmission in the ear. The aim of this study is to clarify the effect of RW reinforcement on hearing. To study the effect of RW reinforcement with tissue and adhesive, we measured intracochlear pressures in scala vestibuli (Psv) and scala tympani (Pst) at the cochlear base together with stapes velocity in response to sound at the ear canal. The cochlear input drive (Pdiff = Psv-Pst, an estimate of hearing) was determined before and after RW reinforcement in a fresh human cadaveric ear. Results show that increasing the RW stiffness by reinforcement can affect the cochlear input drive in unexpected ways. Below 200 Hz, RW reinforcement resulted in reduced stapes motion, however an increase in cochlear drive, consistent with increase in hearing. At 200-1000 Hz, the hearing and stapes motion both were slightly decreased. Reinforcing the RW had no effect above 1 kHz. To understand the cochlear mechanical effects of RW reinforcement, we used a lumped-element model that simulated our findings.
AB - The compliant round window (RW) allows volume velocity to flow within the incompressible fluid of the cochlea as the oval window vibrates during sound stimulation. Recently, surgically stiffened RW is emerging as a treatment for various conditions such as superior canal dehiscence and hyperacusis. However, we lack the basic understanding of how reinforcing the RW affects sound transmission in the ear. The aim of this study is to clarify the effect of RW reinforcement on hearing. To study the effect of RW reinforcement with tissue and adhesive, we measured intracochlear pressures in scala vestibuli (Psv) and scala tympani (Pst) at the cochlear base together with stapes velocity in response to sound at the ear canal. The cochlear input drive (Pdiff = Psv-Pst, an estimate of hearing) was determined before and after RW reinforcement in a fresh human cadaveric ear. Results show that increasing the RW stiffness by reinforcement can affect the cochlear input drive in unexpected ways. Below 200 Hz, RW reinforcement resulted in reduced stapes motion, however an increase in cochlear drive, consistent with increase in hearing. At 200-1000 Hz, the hearing and stapes motion both were slightly decreased. Reinforcing the RW had no effect above 1 kHz. To understand the cochlear mechanical effects of RW reinforcement, we used a lumped-element model that simulated our findings.
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U2 - 10.1063/1.5038529
DO - 10.1063/1.5038529
M3 - Conference contribution
AN - SCOPUS:85048227993
T3 - AIP Conference Proceedings
BT - To the Ear and Back Again - Advances in Auditory Biophysics
A2 - Bergevin, Christopher
A2 - Puria, Sunil
PB - American Institute of Physics Inc.
T2 - 13th Mechanics of Hearing Workshop: To the Ear and Back Again - Advances in Auditory Biophysics, MoH 2017
Y2 - 19 June 2017 through 24 June 2017
ER -