1. 1. Reserpine liberates serotonin readily from blood and tissues and liberates histamine from rabbit blood. In guinea pigs and rabbits histamine was found to be released in part from tissues by reserpine but not as readily or to the same extent as serotonin. 2. 2. The evidence suggests a possible similar type of bond for both histamine and serotonin in platelets but a different type of linkage in tissues. 3. 3. The role of reserpine in producing side effects in patients by histamine release is suggested and discussed.
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