The effect of reserpine on histamine and serotonin

T. Phillip Waalkes, Harriette Coburn, Luther L. Terry

Research output: Contribution to journalArticle

Abstract

1. 1. Reserpine liberates serotonin readily from blood and tissues and liberates histamine from rabbit blood. In guinea pigs and rabbits histamine was found to be released in part from tissues by reserpine but not as readily or to the same extent as serotonin. 2. 2. The evidence suggests a possible similar type of bond for both histamine and serotonin in platelets but a different type of linkage in tissues. 3. 3. The role of reserpine in producing side effects in patients by histamine release is suggested and discussed.

Original languageEnglish (US)
Pages (from-to)408-414
Number of pages7
JournalJournal of Allergy
Volume30
Issue number5
StatePublished - Sep 1959
Externally publishedYes

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Reserpine
Histamine
Serotonin
Rabbits
Histamine Release
Guinea Pigs
Blood Platelets

Cite this

Waalkes, T. P., Coburn, H., & Terry, L. L. (1959). The effect of reserpine on histamine and serotonin. Journal of Allergy, 30(5), 408-414.

The effect of reserpine on histamine and serotonin. / Waalkes, T. Phillip; Coburn, Harriette; Terry, Luther L.

In: Journal of Allergy, Vol. 30, No. 5, 09.1959, p. 408-414.

Research output: Contribution to journalArticle

Waalkes, TP, Coburn, H & Terry, LL 1959, 'The effect of reserpine on histamine and serotonin', Journal of Allergy, vol. 30, no. 5, pp. 408-414.
Waalkes TP, Coburn H, Terry LL. The effect of reserpine on histamine and serotonin. Journal of Allergy. 1959 Sep;30(5):408-414.
Waalkes, T. Phillip ; Coburn, Harriette ; Terry, Luther L. / The effect of reserpine on histamine and serotonin. In: Journal of Allergy. 1959 ; Vol. 30, No. 5. pp. 408-414.
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